Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/412
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dc.contributor.authorDuvel, ADen
dc.contributor.authorSmith, DMen
dc.contributor.authorTalk, Aen
dc.contributor.authorGabriel, Men
dc.date.accessioned2008-06-13T15:20:00Z
dc.date.issued2001en
dc.identifier.citationThe Journal of Neuroscience, 21(9), p. 3271-3281en
dc.identifier.issn0207-6474en
dc.identifier.urihttps://hdl.handle.net/1959.11/412en
dc.description.abstractThis study addressed the neural mediation of discriminative avoidance learning, wherein rabbits step in a wheel apparatus in response to an acoustic conditional stimulus, the CS+, to avoid a foot shock, and they learn to ignore a different stimulus, the CS, not followed by foot shock. Previously, muscimol-induced inactivation of the amygdalar in the first session of training prevented learning during the inactivation and permanently blocked the development of discriminative training-induced neuronal activity (TIA) in the medial division of the medial geniculate nucleus (MGm). These results suggested that amygdalar neurons induce discriminative TIA in the MGm via basolateral (BL) amygdalar axonal projections to the auditory cortex. To test this hypothesis, the activity of neurons in the MGm was recorded during learning in rabbits with lesions of the auditory cortex. Recordings were also made in the lateral and BL amygdalar nuclei and in the cingulate cortex. In support of the hypothesis, discriminative learning in rabbits with lesions was impaired significantly during early training sessions 1-4; in these same sessions, discriminative TIA was abolished in the MGm, the BL nucleus, and the anterior cingulate cortex. The lesions also blocked posterior cingulate cortical discriminative TIA in training sessions 1-2 but spared TIA in sessions 3-7. Lateral amygdalar neurons showed gradual development of discrimination that was not significantly affected by the lesions. The results demonstrate a critical role of auditory cortex in early discriminative learning and in the production of early discriminative TIA in multiple areas.en
dc.languageenen
dc.publisherSociety for Neuroscienceen
dc.relation.ispartofThe Journal of Neuroscienceen
dc.titleMedial Geniculate, Amygdalar and Cingulate Cortical Training-Induced Neuronal Activity during Discriminative Avoidance Learning in Rabbits with Auditory Cortical Lesionsen
dc.typeJournal Articleen
dcterms.accessRightsUNE Greenen
dc.subject.keywordsBiological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)en
local.contributor.firstnameADen
local.contributor.firstnameDMen
local.contributor.firstnameAen
local.contributor.firstnameMen
local.subject.for2008170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)en
local.subject.seo730104 Nervous system and disordersen
local.profile.schoolSchool of Psychology and Behavioural Scienceen
local.profile.emailatalk@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:4993en
local.publisher.placeUnited Statesen
local.format.startpage3271en
local.format.endpage3281en
local.peerreviewedYesen
local.identifier.volume21en
local.identifier.issue9en
local.access.fulltextYesen
local.contributor.lastnameDuvelen
local.contributor.lastnameSmithen
local.contributor.lastnameTalken
local.contributor.lastnameGabrielen
dc.identifier.staffune-id:atalken
local.profile.orcid0000-0002-3449-5756en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:418en
dc.identifier.academiclevelAcademicen
local.title.maintitleMedial Geniculate, Amygdalar and Cingulate Cortical Training-Induced Neuronal Activity during Discriminative Avoidance Learning in Rabbits with Auditory Cortical Lesionsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.urlhttp://www.jneurosci.org/cgi/content/abstract/21/9/3271en
local.description.statisticsepubsVisitors: 324<br />Views: 320<br />Downloads: 5en
local.search.authorDuvel, ADen
local.search.authorSmith, DMen
local.search.authorTalk, Aen
local.search.authorGabriel, Men
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/5983310f-1d96-4299-991a-7674304b20c2en
local.uneassociationUnknownen
local.year.published2001en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/5983310f-1d96-4299-991a-7674304b20c2en
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