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|Title:||Fine-mapping of quantitative trait loci using combined linkage disequilibrium and linkage with general pedigrees||Contributor(s):||Lee, Sang Hong (author); Van Der Werf, Julius Herman (author)||Publication Date:||2007||Handle Link:||https://hdl.handle.net/1959.11/4107||Abstract:||Linkage disequilibrium (LD) information from closely linked markers has been widely used to fine-map quantitative trait loci (QTL). Steps needed for fine-mapping of QTL include inferring inheritance state of markers (haplotyping), estimating identity by descent (IBD) at QTL, and implementing the covariance structure based on IBD into a statistical model. Appropriate pedigree-genotype analysis can estimate more accurate inheritance state and haplotype configuration, which results in more accurate IBD probabilities. A variance component approach can implement covariance coefficients based on IBD probabilities in a mixed linear model to fit additive, dominance and epistasis QTL effects. We have also implemented a reversible jump Markov chain Monte Carlo (MCMC) method for multiple QTL mapping to account for confounding effects between closely linked QTL. Simulation results have shown that this method can improve the precision of mapping QTL.||Publication Type:||Conference Publication||Conference Name:||Association for the Advancement of Animal Breeding and Genetics 2007, Armidale, Australia, 23rd - 26th September, 2007||Conference Details:||Association for the Advancement of Animal Breeding and Genetics 2007, Armidale, Australia, 23rd - 26th September, 2007||Source of Publication:||Proceedings of the Association for the Advancement of Animal Breeding and Genetics, p. 376-382||Publisher:||AAABG: Association for the Advancement of Animal Breeding and Genetics||Place of Publication:||Armidale, NSW, Australia||Field of Research (FOR):||060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)||Peer Reviewed:||Yes||HERDC Category Description:||E1 Refereed Scholarly Conference Publication||Other Links:||http://www.aaabg.org/livestocklibrary/2007/lee376.pdf||Statistics to Oct 2018:||Visitors: 189
|Appears in Collections:||Conference Publication|
School of Environmental and Rural Science
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