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https://hdl.handle.net/1959.11/3958
Title: | Developmental Mosaicism May Explain Spontaneous Reappearance of the Axin^Fu Mutation in Mice | Contributor(s): | Ruvinsky, Anatoly (author); Flood, Warren (author); Constantini, Frank (author) | Publication Date: | 2001 | Handle Link: | https://hdl.handle.net/1959.11/3958 | Abstract: | The Axin^Fu mutation is caused by an IAP insertion. In a small percentage of mice, the Axin^Fu mutation disappears and is not observed in the next generation. In these mice, [Axin^Fu]/+, the IAP is absent and Axin^Fu has reverted to the wild allele. Concomitantly with the loss of IAP, there is widespread reorganisation of numerous microsatellite loci across the surrounding region of chromosome. In rare cases, spontaneous reappearance of the mutation can be observed in progeny of [Axin^Fu]/+mice. It is revealed here that reappearance of Axin^Fu was associated with restoration of the IAP insertion. In such mice, alleles of the surrounding microsatellite loci were identical to the alleles observed on chromosomes that carried Axin^Fu. Developmental mosaicism can potentially explain spontaneous reappearance of the Axin^Fu mutation. Mosaicism can also explain other observations including postnatal changes at the Axin locus, unusual segregation in progeny, and the appearance of [Axin^Fu]/+ mice that were phenotypically mutant. | Publication Type: | Journal Article | Source of Publication: | Genesis: The Journal of Genetics and Development, 29(2), p. 49-54 | Publisher: | John Wiley & Sons, Inc | Place of Publication: | United States of America | ISSN: | 1526-968X 1526-954X |
Fields of Research (FoR) 2008: | 060405 Gene Expression (incl Microarray and other genome-wide approaches) | Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences | HERDC Category Description: | C4 Letter of Note | Publisher/associated links: | http://dx.doi.org/10.1002/1526-968X(200102)29:2<49 |
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Appears in Collections: | Journal Article |
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