Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3936
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dc.contributor.authorTyler, Richard Sen
dc.contributor.authorOleson, Jacoben
dc.contributor.authorNoble, William Glassen
dc.contributor.authorCoelho, Claudiaen
dc.contributor.authorJi, Helenaen
dc.date.accessioned2009-12-18T16:10:00Z
dc.date.issued2007en
dc.identifier.citationProgress in Brain Research, v.166, p. 499-509en
dc.identifier.issn1875-7855en
dc.identifier.issn0079-6123en
dc.identifier.urihttps://hdl.handle.net/1959.11/3936en
dc.description.abstractWe review a few issues related to clinical trials for treating patients with tinnitus, including the study population, design, choice of measurement variables, and some new approaches to data analysis. We emphasize the importance of being aware of different subgroups of tinnitus patients, and that patients who have had tinnitus for less than 6 months could be more amenable to treatment than patients who have had their tinnitus for a longer period. We distinguish the tinnitus itself, from the reactions to the tinnitus. When the treatment is intended to reduce the tinnitus, we recommend measuring the magnitude of the tinnitus. We provide arguments and data to support the use of the Tinnitus Handicap Questionnaire as a measure of the reaction to the tinnitus. We suggest that the current quality of life measures are not valid for measuring lifestyle effects of alleviating tinnitus. Because tinnitus likely has different subgroups, and because tinnitus affects people differently, we believe data analysis should emphasize individuals, not groups. A clinically meaningful effect should represent a valid and reliable statistical change for an individual.en
dc.languageenen
dc.publisherElsevier BVen
dc.relation.ispartofProgress in Brain Researchen
dc.titleClinical trials for tinnitus: study populations, designs, measurement variables, and data analysisen
dc.typeJournal Articleen
dc.identifier.doi10.1016/S0079-6123(07)66048-8en
dc.subject.keywordsSensory Processes, Perception and Performanceen
local.contributor.firstnameRichard Sen
local.contributor.firstnameJacoben
local.contributor.firstnameWilliam Glassen
local.contributor.firstnameClaudiaen
local.contributor.firstnameHelenaen
local.subject.for2008170112 Sensory Processes, Perception and Performanceen
local.subject.seo2008920107 Hearing, Vision, Speech and Their Disordersen
local.profile.schoolAdministrationen
local.profile.emailwnoble@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:5878en
local.publisher.placeNetherlandsen
local.format.startpage499en
local.format.endpage509en
local.peerreviewedYesen
local.identifier.volume166en
local.title.subtitlestudy populations, designs, measurement variables, and data analysisen
local.contributor.lastnameTyleren
local.contributor.lastnameOlesonen
local.contributor.lastnameNobleen
local.contributor.lastnameCoelhoen
local.contributor.lastnameJien
dc.identifier.staffune-id:wnobleen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:4033en
dc.identifier.academiclevelAcademicen
local.title.maintitleClinical trials for tinnitusen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 117<br />Views: 148<br />Downloads: 0en
local.search.authorTyler, Richard Sen
local.search.authorOleson, Jacoben
local.search.authorNoble, William Glassen
local.search.authorCoelho, Claudiaen
local.search.authorJi, Helenaen
local.uneassociationUnknownen
local.year.published2007en
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