Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3859
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dc.contributor.authorMcFarlane, James Roberten
dc.contributor.authorXia, Yen
dc.contributor.authorO'Shea, Timothyen
dc.contributor.authorHayward, Sen
dc.contributor.authorO'Connor, Aen
dc.contributor.authorKretser, D Men
dc.date.accessioned2009-12-16T16:05:00Z
dc.date.issued2002en
dc.identifier.citationReproduction, 124(2), p. 259-265en
dc.identifier.issn1741-7899en
dc.identifier.issn1470-1626en
dc.identifier.urihttps://hdl.handle.net/1959.11/3859en
dc.description.abstractThe aim of this study was to investigate the changes in follistatin, an activin binding protein, during the oestrous cycle, gestation and parturition in ewes using a radioimmunoassay for total follistatin, which uses dissociating reagents to remove the interference of activin. Follistatin concentrations remained unchanged (2.7 ± 0.2 ng ml⁻¹) during the oestrous cycle and decreased as pregnancy progressed. Follistatin concentrations in allantoic fluid also decreased during gestation, whereas in amniotic fluid follistatin concentrations reached a peak at day 75 of gestation (9.8 ng ml⁻¹) and had decreased to 4.4 ng ml⁻¹ at day 140. Follistatin concentrations in fetal blood (7.0 ± 0.5 ng ml⁻¹) did not change from day 50 to day 140 of gestation but were significantly higher than in matched maternal samples (3.1 ± 0.3 ng ml⁻¹). Circulating follistatin in ewes was significantly increased on the day of parturition (5.6 ± 0.6 ng ml⁻¹) compared with the days before parturition (2.7 ± 0.4 ng ml⁻¹), but had decreased by day 2 after birth. Blood samples from newborn lambs showed that plasma follistatin concentration (13.4 ± 2.3 ng ml⁻¹) was significantly higher than that of the mothers and remained high for at least 7 days after birth. These data support previous studies of the human menstrual cycle indicating that follistatin is not an endocrine signal from the ovary; however, in contrast to human pregnancies, follistatin concentrations in sheep decreased and become high only after or during parturition. This difference observed between species may reflect different physiological effects of follistatin or may be the result of measurement of different isoforms.en
dc.languageenen
dc.publisherBioScientifica Ltden
dc.relation.ispartofReproductionen
dc.titleFollistatin concentrations in maternal and fetal fluids during the oestrous cycle, gestation and parturition in Merino sheepen
dc.typeJournal Articleen
dc.identifier.doi10.1530/rep.0.1240259en
dc.subject.keywordsMetabolic Medicineen
dc.subject.keywordsReproductionen
dc.subject.keywordsEndocrinologyen
local.contributor.firstnameJames Roberten
local.contributor.firstnameYen
local.contributor.firstnameTimothyen
local.contributor.firstnameSen
local.contributor.firstnameAen
local.contributor.firstnameD Men
local.subject.for2008110107 Metabolic Medicineen
local.subject.for2008111404 Reproductionen
local.subject.for2008110306 Endocrinologyen
local.subject.seo2008920114 Reproductive System and Disordersen
local.subject.seo2008920106 Endocrine Organs and Diseases (excl. Diabetes)en
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjmcfarla@une.edu.auen
local.profile.emailtoshea2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:7090en
local.publisher.placeBristol, UKen
local.format.startpage259en
local.format.endpage265en
local.peerreviewedYesen
local.identifier.volume124en
local.identifier.issue2en
local.contributor.lastnameMcFarlaneen
local.contributor.lastnameXiaen
local.contributor.lastnameO'Sheaen
local.contributor.lastnameHaywarden
local.contributor.lastnameO'Connoren
local.contributor.lastnameKretseren
dc.identifier.staffune-id:jmcfarlaen
dc.identifier.staffune-id:tosheaen
local.profile.orcid0000-0003-4429-5384en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:3954en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleFollistatin concentrations in maternal and fetal fluids during the oestrous cycle, gestation and parturition in Merino sheepen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 414<br />Views: 438<br />Downloads: 0en
local.search.authorMcFarlane, James Roberten
local.search.authorXia, Yen
local.search.authorO'Shea, Timothyen
local.search.authorHayward, Sen
local.search.authorO'Connor, Aen
local.search.authorKretser, D Men
local.uneassociationUnknownen
local.year.published2002en
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