Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/3859
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | McFarlane, J R | en |
dc.contributor.author | Xia, Y | en |
dc.contributor.author | O'Shea, T | en |
dc.contributor.author | Hayward, S | en |
dc.contributor.author | O'Connor, A E | en |
dc.contributor.author | de Kretser, D M | en |
dc.date.accessioned | 2009-12-16T16:05:00Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Reproduction, 124(2), p. 259-265 | en |
dc.identifier.issn | 1741-7899 | en |
dc.identifier.issn | 1470-1626 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/3859 | - |
dc.description.abstract | The aim of this study was to investigate the changes in follistatin, an activin binding protein, during the oestrous cycle, gestation and parturition in ewes using a radioimmunoassay for total follistatin, which uses dissociating reagents to remove the interference of activin. Follistatin concentrations remained unchanged (2.7 ± 0.2 ng ml⁻¹) during the oestrous cycle and decreased as pregnancy progressed. Follistatin concentrations in allantoic fluid also decreased during gestation, whereas in amniotic fluid follistatin concentrations reached a peak at day 75 of gestation (9.8 ng ml⁻¹) and had decreased to 4.4 ng ml⁻¹ at day 140. Follistatin concentrations in fetal blood (7.0 ± 0.5 ng ml⁻¹) did not change from day 50 to day 140 of gestation but were significantly higher than in matched maternal samples (3.1 ± 0.3 ng ml⁻¹). Circulating follistatin in ewes was significantly increased on the day of parturition (5.6 ± 0.6 ng ml⁻¹) compared with the days before parturition (2.7 ± 0.4 ng ml⁻¹), but had decreased by day 2 after birth. Blood samples from newborn lambs showed that plasma follistatin concentration (13.4 ± 2.3 ng ml⁻¹) was significantly higher than that of the mothers and remained high for at least 7 days after birth. These data support previous studies of the human menstrual cycle indicating that follistatin is not an endocrine signal from the ovary; however, in contrast to human pregnancies, follistatin concentrations in sheep decreased and become high only after or during parturition. This difference observed between species may reflect different physiological effects of follistatin or may be the result of measurement of different isoforms. | en |
dc.language | en | en |
dc.publisher | BioScientifica Ltd | en |
dc.relation.ispartof | Reproduction | en |
dc.title | Follistatin concentrations in maternal and fetal fluids during the oestrous cycle, gestation and parturition in Merino sheep | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1530/rep.0.1240259 | en |
dc.subject.keywords | Metabolic Medicine | en |
dc.subject.keywords | Reproduction | en |
dc.subject.keywords | Endocrinology | en |
local.contributor.firstname | J R | en |
local.contributor.firstname | Y | en |
local.contributor.firstname | T | en |
local.contributor.firstname | S | en |
local.contributor.firstname | A E | en |
local.contributor.firstname | D M | en |
local.subject.for2008 | 110107 Metabolic Medicine | en |
local.subject.for2008 | 111404 Reproduction | en |
local.subject.for2008 | 110306 Endocrinology | en |
local.subject.seo2008 | 920114 Reproductive System and Disorders | en |
local.subject.seo2008 | 920106 Endocrine Organs and Diseases (excl. Diabetes) | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.email | jmcfarla@une.edu.au | en |
local.profile.email | toshea2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | pes:7090 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 259 | en |
local.format.endpage | 265 | en |
local.identifier.scopusid | 0036051823 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 124 | en |
local.identifier.issue | 2 | en |
local.contributor.lastname | McFarlane | en |
local.contributor.lastname | Xia | en |
local.contributor.lastname | O'Shea | en |
local.contributor.lastname | Hayward | en |
local.contributor.lastname | O'Connor | en |
local.contributor.lastname | de Kretser | en |
dc.identifier.staff | une-id:jmcfarla | en |
dc.identifier.staff | une-id:toshea | en |
local.profile.orcid | 0000-0003-4429-5384 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:3954 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Follistatin concentrations in maternal and fetal fluids during the oestrous cycle, gestation and parturition in Merino sheep | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | McFarlane, J R | en |
local.search.author | Xia, Y | en |
local.search.author | O'Shea, T | en |
local.search.author | Hayward, S | en |
local.search.author | O'Connor, A E | en |
local.search.author | de Kretser, D M | en |
local.uneassociation | Unknown | en |
local.year.published | 2002 | en |
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.