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|Title:||Effect of Short-Term and Long-Term Antioxidant Therapy on Primary and Secondary Ageing Neurovascular Processes||Contributor(s):||Khodr, Bereha (author); Howard, Jonathon (author); Watson, Kenneth (author); Khalil, Zeinab (author)||Publication Date:||2003||Handle Link:||https://hdl.handle.net/1959.11/3845||Abstract:||Previous studies from our laboratory demonstrated an age-related functional decline in sensory neurones and their modulation of microvascular blood flow (primary ageing processes) that correlated with a deficiency in tissue repair (a secondary ageing process).We also raised the notion of a possible role for free radicals in these age-related changes. The aim of this study was to investigate the impact of antioxidant therapy on modulating sensory neurovascular function and tissue repair with age. Twenty-four-month-old Sprague-Dawley rats were treated with vitamin E for short-term (40 mg/kg, i.p., every other day for 2 weeks) or long-term (for 12 months in advance, 10 g/kg, incorporated in food). These treated rats were assessed for the effectiveness of treatment and tested for their sensory neurovascular function, repair of full-thickness burn, and recovery from hyperalgesia following nerve injury. The results indicate that both short- and longterm vitamin E treatments are effective in improving sensory neurovascular function and in reducing the time required for complete wound closure of full-thickness burn injury. Short-term vitamin E treatment was more effective in protecting against the development of hyperalgesia following nerve injury. An initial increase in wound size and in hyperalgesia was observed in the treated animals, and could reflect possible side effects of the antioxidant therapy and support the importance of free radicals in early stages of the repair process. The data, overall, support the notion that oxidative damage contributes to both primary and secondary ageing processes.||Publication Type:||Journal Article||Source of Publication:||Journal of Gerontology, 58A(8), p. 698-708||Publisher:||Gerontological Society of America||Place of Publication:||USA||ISSN:||1758-535X
|Field of Research (FOR):||110308 Geriatrics and Gerontology||Socio-Economic Outcome Codes:||920502 Health Related to Ageing||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Other Links:||http://biomed.gerontologyjournals.org/cgi/content/abstract/58/8/B698||Statistics to Oct 2018:||Visitors: 88
|Appears in Collections:||Journal Article|
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