Wilke, Vicki L

Conzemius, Michael G

Kinghorn, Brian

Macrossan, Paula Elizabeth

Cai, Weiguo

Rothschild, Max F

2006

Objective - To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands. Design - Retrospective and recruitment study. Animals - 574 client-owned Newfoundlands. Procedure - Medical records from January 1, 1996, to December 31, 2002, were evaluated for prevalence of RCCL. A pedigree was constructed by use of recruited Newfoundlands with RCCL status based on results of veterinary examination; level of inbreeding, heritability, and mode of inheritance were calculated. Results - Hospital prevalence for RCCL was 22%; dogs in the pedigree from the recruitment study had a mean level of inbreeding of 1.19 X 10–4, heritability of 0.27, and a possible recessive mode of inheritance with 51% penetrance for RCCL. Conclusions and Clinical Relevance - Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.

Journal of the American Veterinary Medical Association, 228(1), p. 61-64

1943-569X

0003-1488

https://hdl.handle.net/1959.11/3781

en

American Veterinary Medical Association (AVMA)

Inheritance of rupture of the cranial cruciate ligament in Newfoundlands

Journal Article

Publication