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Title: Inheritance of rupture of the cranial cruciate ligament in Newfoundlands
Contributor(s): Wilke, Vicki L (author); Conzemius, Michael G (author); Kinghorn, Brian  (author); Macrossan, Paula Elizabeth (author); Cai, Weiguo (author); Rothschild, Max F (author)
Publication Date: 2006
DOI: 10.2460/javma.228.1.61
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Abstract: Objective - To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands. Design - Retrospective and recruitment study. Animals - 574 client-owned Newfoundlands. Procedure - Medical records from January 1, 1996, to December 31, 2002, were evaluated for prevalence of RCCL. A pedigree was constructed by use of recruited Newfoundlands with RCCL status based on results of veterinary examination; level of inbreeding, heritability, and mode of inheritance were calculated. Results - Hospital prevalence for RCCL was 22%; dogs in the pedigree from the recruitment study had a mean level of inbreeding of 1.19 X 10–4, heritability of 0.27, and a possible recessive mode of inheritance with 51% penetrance for RCCL. Conclusions and Clinical Relevance - Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.
Publication Type: Journal Article
Source of Publication: Journal of the American Veterinary Medical Association, 228(1), p. 61-64
Publisher: AVMA: American Veterinary Medical Association
Place of Publication: United States of America
ISSN: 1943-569X
Field of Research (FOR): 070201 Animal Breeding
Socio-Economic Objective (SEO): 839999 Animal Production and Animal Primary Products not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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