Differential Gene Expression in Longissimus Dorsi Muscle of Hanwoo Steers-New Insight in Genes Involved in Marbling Development at Younger Ages

Author(s)
de las Heras-Saldana, Sara
Chung, Ki Yong
Kim, Hyounju
Lim, Dajeong
Gondro, Cedric
van der Werf, Julius H J
Publication Date
2020-11
Abstract
<p>The Korean Hanwoo breed possesses a high capacity to accumulate intramuscular fat, which is measured as a marbling score in the beef industry. Unfortunately, the development of marbling is not completely understood and the identification of differentially expressed genes at an early age is required to better understand this trait. In this study, we took muscle samples from 12 Hanwoo steers at the age of 18 and 30 months. From the contrast between age and marbling score, we identified in total 1883 differentially expressed genes (FDR < 0.05 and logarithm fold change ≥ 1.5) with 782 genes up-regulated and 1101 down-regulated. Differences in gene expression were higher between the ages x marbling groups rather than between high and low marbling groups. At 18 months of age, the genes <i>SLC38A4, ABCA10, APOL6</i>, and two novel genes (ENSBTAG00000015330 and ENSBTAG00000046041) were up-regulated in the high marbling group. From the protein-protein interaction network analysis, we identified unique networks when comparing marbling scores between different ages. Nineteen genes (<i>AGT, SERPINE1, ADORA1, FOS, LEP, FOXO1, FOXO3, ADIPOQ, ITGA1, SDC1, SDC4, ITGB3, ITGB4, CXCL10, ACTG2, MX1, EDN1, ACTA2</i>, and <i>ESPL1</i>) were identified to have an important role in marbling development. Further analyses are needed to better understand the role of these genes.</p>
Citation
Genes, 11(11), p. 1-17
ISSN
2073-4425
Pubmed ID
33233382
Link
Publisher
MDPI AG
Rights
Attribution 4.0 International
Title
Differential Gene Expression in Longissimus Dorsi Muscle of Hanwoo Steers-New Insight in Genes Involved in Marbling Development at Younger Ages
Type of document
Journal Article
Entity Type
Publication

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