Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3691
Title: Suggestive Linkage on Chromosome 2, 8 and 17 for Lifetime Major Depression
Contributor(s): Middeldorp, Christel M (author); Sullivan, Patrick F (author); Slagboom, P Eline (author); Boomsma, Dorret I (author); Martin, Nicholas G (author); Wray, Naomi R (author); Hottenga, Jouke-Jan (author); de Geus, Eco J C (author); van den Berg, Mireille (author); Montgomery, Grant W (author); Coventry, William Luya  (author)orcid ; Statham, Dixie J (author); Andrews, Gavin (author)
Publication Date: 2007
DOI: 10.1002/ajmg.b.30817
Handle Link: https://hdl.handle.net/1959.11/3691
Abstract: It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2.
Publication Type: Journal Article
Source of Publication: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 150B(3), p. 352-358
Publisher: John Wiley & Sons, Inc
Place of Publication: United States of America
ISSN: 1552-485X
1552-4841
Fields of Research (FoR) 2008: 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
Socio-Economic Objective (SEO) 2008: 920410 Mental Health
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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