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Title: The profile and incidence of cancer in Down syndrome
Contributor(s): Sullivan, S (author); Hussain, Rafat  (author); Glasson, E (author); Bittles, A (author)
Publication Date: 2007
DOI: 10.1111/j.1365-2788.2006.00862.x
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Abstract: Background: Down syndrome is one of the commonest causes of intellectual disability. As life expectancy improves with early and more intensive surgical and medical treatments, people with the disorder are more likely to exhibit classic morbidity and mortality patterns and be diagnosed with diseases such as cancer. Methods: A profile of cancer cases among people with Down syndrome has been compiled, based on the analysis of a linked data set that included information from the Disability Services Commission of Western Australian and the State Cancer Registry. Results and conclusions: Although the total age- and sex-standardized incidence ratios (SIRs) for people with Down syndrome were similar to that for the general population, SIRs for leukaemia were significantly higher while the incidence of certain other types of cancers was reduced. Overall, there was a lower incidence of solid tumours in Down syndrome, possibly reflecting the age profile of the study cohort.
Publication Type: Journal Article
Source of Publication: Journal of Intellectual Disability Research, 51(3), p. 228-231
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: London, United Kingdom
ISSN: 1351-0886
Field of Research (FOR): 111703 Care for Disabled
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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