Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3616
Title: Imaging lung aeration and lung liquid clearance at birth
Contributor(s): Hooper, Stuart B (author); Kitchen, Marcus J (author); Irvine, Sarah C (author); Pavlov, Konstantin M  (author)orcid ; Lewis, Robert A (author); Wallace, Megan J (author); Yagi, Naoto (author); Uesugi, Kentaro (author); Morgan, Michael J (author); Hall, Chris (author); Siu, Karen K W (author); Williams, Ivan M (author); Siew, Melissa (author)
Publication Date: 2007
DOI: 10.1096/fj.07-8208com
Handle Link: https://hdl.handle.net/1959.11/3616
Abstract: Aeration of the lung and the transition to air-breathing at birth is fundamental to mammalian life and initiates major changes in cardiopulmonary physiology. However, the dynamics of this process and the factors involved are largely unknown, because it has not been possible to observe or measure lung aeration on a breath-by-breath basis. We have used the high contrast and spatial resolution of phase contrast X-ray imaging to study lung aeration at birth in spontaneously breathing neonatal rabbits. As the liquid-filled fetal lungs provide little absorption or phase contrast, they are not visible and only become visible as they aerate, allowing a detailed examination of this process. Pups were imaged live from birth to determine the timing and spatial pattern of lung aeration, and relative levels of lung aeration were measured from the images using a power spectral analysis. We report the first detailed observations and measurements of lung aeration, demonstrating its dependence on inspiratory activity and body position; dependent regions aerated at much slower rates. The air/liquid interface moved toward the distal airways only during inspiration, with little proximal movement during expiration, indicating that transpulmonary pressures play an important role in airway liquid clearance at birth. Using these imaging techniques, the dynamics of lung aeration and the critical role it plays in regulating the physiological changes at birth can be fully explored.—Hooper, S. B., Kitchen, M. J., Wallace, M. J., Yagi, N., Uesugi, K., Morgan, M. J., Hall, C., Siu, K. K. W., Williams, I. M., Siew, M., Irvine, S. C., Pavlov, K., Lewis, R. A. Imaging lung aeration and lung liquid clearance at birth. FASEB J. 21, 3329–3337 (2007)
Publication Type: Journal Article
Source of Publication: FASEB Journal, 21(12), p. 3329-3337
Publisher: Federation of American Societies for Experimental Biology
Place of Publication: United States of America
ISSN: 1530-6860
0892-6638
Fields of Research (FoR) 2008: 110320 Radiology and Organ Imaging
091599 Interdisciplinary Engineering not elsewhere classified
111403 Paediatrics
Socio-Economic Objective (SEO) 2008: 970111 Expanding Knowledge in the Medical and Health Sciences
861503 Scientific Instruments
861502 Medical Instruments
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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