Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to 'Trypanosoma congolense' infection

Title
Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to 'Trypanosoma congolense' infection
Publication Date
2003
Author(s)
Nakamura, Yoshio
Naessens, Jan
Takata, Masuhiro
Taniguchi, Takahide
Sekikawa, Kenji
Gibson, John Paul
Iraqi, Fuad
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Springer
Place of publication
Germany
UNE publication id
une:3666
Abstract
The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to 'Trypanosoma congolense' infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HSP70.1-deficient C57BL/6 J, resistant wild-type C57BL/6 J and susceptible A/J mice. No differences were observed between HSP70.1-deficient and wild-type C57BL/6 J mice in survival time, levels of parasitemia and anemia, suggesting that there is no involvement of the HSP70.1 gene in control of 'T. congolense' infection. The course of infection was markedly different between A/J and C57BL/6 J mice. A/J mice showed a bi-phasic survival pattern, which seemed to be associated with two waves of high parasitemia, but developed only moderate anemia. C57BL/6 J mice controlled parasitemia well but developed severe anemia in the late stage of infection.
Link
Citation
Parasitology Research, 90(2), p. 171-174
ISSN
1432-1955
0932-0113
Start page
171
End page
174

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