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Title: Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to 'Trypanosoma congolense' infection
Contributor(s): Nakamura, Yoshio (author); Naessens, Jan (author); Takata, Masuhiro (author); Taniguchi, Takahide (author); Sekikawa, Kenji (author); Gibson, John Paul  (author); Iraqi, Fuad (author)
Publication Date: 2003
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Abstract: The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to 'Trypanosoma congolense' infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HSP70.1-deficient C57BL/6 J, resistant wild-type C57BL/6 J and susceptible A/J mice. No differences were observed between HSP70.1-deficient and wild-type C57BL/6 J mice in survival time, levels of parasitemia and anemia, suggesting that there is no involvement of the HSP70.1 gene in control of 'T. congolense' infection. The course of infection was markedly different between A/J and C57BL/6 J mice. A/J mice showed a bi-phasic survival pattern, which seemed to be associated with two waves of high parasitemia, but developed only moderate anemia. C57BL/6 J mice controlled parasitemia well but developed severe anemia in the late stage of infection.
Publication Type: Journal Article
Source of Publication: Parasitology Research, 90(2), p. 171-174
Publisher: Springer-Verlag
Place of Publication: Berlin/Heidelberg, Germany
ISSN: 0932-0113
Field of Research (FOR): 070201 Animal Breeding
Socio-Economic Objective (SEO): 830399 Livestock Raising not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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