Effects of Conditioning During Amygdalar Inactivation on Training-Induced Neuronal Plasticity in the Medial Geniculate Nucleus and Cingulate Cortex in Rabbits ('Oryctolagus cuniculus')

Talk, Andrew; Kashef, Alireza; Gabriel, Michael

doi:10.1037/0735-7044.118.5.944

Author(s)

Talk, Andrew

Kashef, Alireza

Gabriel, Michael

Publication Date

2004

Abstract

This study addressed the amygdala's role in avoidance conditioning in rabbits ('Oryctolagus cuniculus'). Intra-amygdalar muscimol infusion before 60 or 120 conditioning trials blocked training-induced neuronal activity (TIA) in the medial geniculate (MG) nucleus. One hundred twenty trials with muscimol blocked TIA permanently, during conditioning with muscimol and then later without muscimol; 60 trials with muscimol blocked TIA only when muscimol was present. Cingulate cortical TIA was blocked only when muscimol was present. Behavioral learning did not occur with muscimol, but later learning was facilitated (i.e., savings occurred) in rabbits initially given muscimol plus training. These results define the time period wherein amygdalar processes initiate TIA in the MG nucleus and suggest that distinct forms of amygdalar processes induce TIA in the MG nucleus and cingulate cortex.

Citation

Behavioral Neuroscience, 118(5), p. 944-955

ISSN

1939-0084

0735-7044

Link

https://hdl.handle.net/1959.11/3568

Language

en

Publisher

American Psychological Association

Title

Effects of Conditioning During Amygdalar Inactivation on Training-Induced Neuronal Plasticity in the Medial Geniculate Nucleus and Cingulate Cortex in Rabbits ('Oryctolagus cuniculus')

Type of document

Journal Article

Entity Type

Publication

Author(s)	Talk, Andrew Kashef, Alireza Gabriel, Michael
Publication Date	2004
Abstract	This study addressed the amygdala's role in avoidance conditioning in rabbits ('Oryctolagus cuniculus'). Intra-amygdalar muscimol infusion before 60 or 120 conditioning trials blocked training-induced neuronal activity (TIA) in the medial geniculate (MG) nucleus. One hundred twenty trials with muscimol blocked TIA permanently, during conditioning with muscimol and then later without muscimol; 60 trials with muscimol blocked TIA only when muscimol was present. Cingulate cortical TIA was blocked only when muscimol was present. Behavioral learning did not occur with muscimol, but later learning was facilitated (i.e., savings occurred) in rabbits initially given muscimol plus training. These results define the time period wherein amygdalar processes initiate TIA in the MG nucleus and suggest that distinct forms of amygdalar processes induce TIA in the MG nucleus and cingulate cortex.
Citation	Behavioral Neuroscience, 118(5), p. 944-955
ISSN	1939-0084 0735-7044
Link	https://hdl.handle.net/1959.11/3568
Language	en
Publisher	American Psychological Association
Title	Effects of Conditioning During Amygdalar Inactivation on Training-Induced Neuronal Plasticity in the Medial Geniculate Nucleus and Cingulate Cortex in Rabbits ('Oryctolagus cuniculus')
Type of document	Journal Article
Entity Type	Publication

Effects of Conditioning During Amygdalar Inactivation on Training-Induced Neuronal Plasticity in the Medial Geniculate Nucleus and Cingulate Cortex in Rabbits ('Oryctolagus cuniculus')

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