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|Title:||Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences||Contributor(s):||Agnew, Linda (author) ; Guffogg, Sharon Patricia (author); Matthias, A (author); Lehmann, R P (author); Bone, Kerry (author); Watson, Kenneth (author)||Publication Date:||2005||DOI:||10.1111/j.1365-2710.2005.00658.x||Handle Link:||https://hdl.handle.net/1959.11/3489||Abstract:||Objective: To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. Method: Eleven healthy individuals (26–61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days. Results: Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P = 0·029). White cell counts (WCC) were also increased (P = 0·043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P = 0·006) indicative of an antioxidant effect. Conclusion: The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC.||Publication Type:||Journal Article||Source of Publication:||Journal of Clinical Pharmacy and Therapeutics, 30(4), p. 363-369||Publisher:||Wiley-Blackwell Publishing||Place of Publication:||Abingdon, United Kingdom||ISSN:||0269-4727||Field of Research (FOR):||110203 Respiratory Diseases||Socio-Economic Outcome Codes:||920412 Preventive Medicine||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 556
|Appears in Collections:||Journal Article|
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