Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3489
Title: Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences
Contributor(s): Agnew, Linda  (author)orcid ; Guffogg, Sharon Patricia (author); Matthias, A (author); Lehmann, R P (author); Bone, Kerry (author); Watson, Kenneth  (author)
Publication Date: 2005
DOI: 10.1111/j.1365-2710.2005.00658.x
Handle Link: https://hdl.handle.net/1959.11/3489
Abstract: Objective: To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. Method: Eleven healthy individuals (26–61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days. Results: Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P = 0·029). White cell counts (WCC) were also increased (P = 0·043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P = 0·006) indicative of an antioxidant effect. Conclusion: The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC.
Publication Type: Journal Article
Source of Publication: Journal of Clinical Pharmacy and Therapeutics, 30(4), p. 363-369
Publisher: Wiley-Blackwell Publishing
Place of Publication: Abingdon, United Kingdom
ISSN: 0269-4727
Field of Research (FOR): 110203 Respiratory Diseases
Socio-Economic Outcome Codes: 920412 Preventive Medicine
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 556
Views: 559
Downloads: 0
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

17
checked on Nov 30, 2018

Page view(s)

100
checked on Mar 4, 2019
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.