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Title: Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences
Contributor(s): Agnew, Linda  (author)orcid ; Guffogg, Sharon Patricia (author); Matthias, A (author); Lehmann, R P (author); Bone, Kerry (author); Watson, Kenneth  (author)
Publication Date: 2005
DOI: 10.1111/j.1365-2710.2005.00658.x
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Abstract: Objective: To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. Method: Eleven healthy individuals (26–61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days. Results: Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P = 0·029). White cell counts (WCC) were also increased (P = 0·043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P = 0·006) indicative of an antioxidant effect. Conclusion: The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC.
Publication Type: Journal Article
Source of Publication: Journal of Clinical Pharmacy and Therapeutics, 30(4), p. 363-369
Publisher: Wiley-Blackwell Publishing
Place of Publication: Abingdon, United Kingdom
ISSN: 0269-4727
Field of Research (FOR): 110203 Respiratory Diseases
Socio-Economic Outcome Codes: 920412 Preventive Medicine
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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