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https://hdl.handle.net/1959.11/3388
Title: | In vivo evidence of role of bone morphogenetic protein-4 in the mouse ovary | Contributor(s): | Tanwar, Pradeep Singh (author); O'Shea, Timothy (author); McFarlane, James R (author) | Publication Date: | 2008 | Handle Link: | https://hdl.handle.net/1959.11/3388 | Abstract: | The transition of a primordial follicle to a primary follicle is an early step in folliculogenesis. All female mammals are born with a fixed stock of primordial follicles, and exhaustion of that stock leads to menopause or infertility. Recently, several in vitro studies have indicated that BMP-4, BMP-7, and several other growth factors affect the transition of primordial to primary follicles. The aim of our present study was to investigate role of BMP-4 in this process using passive immunization to investigate the role of BMP-4 in a prepubertal mouse model. After seven days of treatment, the weight of antiBMP-4 treated ovaries was significantly lower than the ovaries from mice treated with nonimmune Ig. The number of primary follicles was lower, and the numbers of primordial follicles were higher in antiBMP-4 treated ovaries compared to control ovaries. Treatment with equine chorionic gonadotrophin (eCG) showed no influence on the effects of antiBMP-4 in the mouse ovary. Thus, the results of our study indicate that in vivo BMP-4 acts as transition factor in transition of primordial to primary follicle. | Publication Type: | Journal Article | Source of Publication: | Animal Reproduction Science, 106(3-4), p. 232-240 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1873-2232 0378-4320 |
Fields of Research (FoR) 2008: | 110306 Endocrinology 111404 Reproduction |
Socio-Economic Objective (SEO) 2008: | 920114 Reproductive System and Disorders | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal | Publisher/associated links: | https://doi.org/10.1016/j.anireprosci.2007.04.015 |
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Appears in Collections: | Journal Article |
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