Fine mapping of multiple interacting quantitative trait loci using combined linkage disequilibrium and linkage information

Title
Fine mapping of multiple interacting quantitative trait loci using combined linkage disequilibrium and linkage information
Publication Date
2007
Author(s)
Lee, Sang Hong
Van Der Werf, Julius Herman
( author )
OrcID: https://orcid.org/0000-0003-2512-1696
Email: jvanderw@une.edu.au
UNE Id une-id:jvanderw
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Zhejiang University Press
Place of publication
China
DOI
10.1631/jzus.2007.B0787
UNE publication id
une:3392
Abstract
Quantitative trait loci (QTL) and their additive, dominance and epistatic effects play a critical role in complex trait variation. It is often infeasible to detect multiple interacting QTL due to main effects often being confounded by interaction effects. Positioning interacting QTL within a small region is even more difficult. We present a variance component approach nested in an empirical Bayesian method, which simultaneously takes into account additive, dominance and epistatic effects due to multiple interacting QTL. The covariance structure used in the variance component approach is based on combined linkage disequilibrium and linkage (LDL) information. In a simulation study where there are complex epistatic interactions between QTL, it is possible to simultaneously fine map interacting QTL using the proposed approach. The present method combined with LDL information can efficiently detect QTL and their dominance and epistatic effects, making it possible to simultaneously fine map main and epistatic QTL.
Link
Citation
Journal of Zhejiang University. Science B, 8(11), p. 787-791
ISSN
1862-1783
1673-1581
Start page
787
End page
791

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