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https://hdl.handle.net/1959.11/3257| Title: | Confirmation and dissection of QTL controlling resistance to malaria in mice | Contributor(s): | Hernandez-Valladares, Maria (author); Naessens, Jan (author); Gibson, John Paul (author); Musoke, Anthony J (author); Nagda, Sonal (author); Rihet, Pascal (author); ole-MoiYoi, Onesmo K (author); Iraqi, Fuad A (author) | Publication Date: | 2004 | DOI: | 10.1007/s00335-004-3042-4 | Handle Link: | https://hdl.handle.net/1959.11/3257 | Abstract: | We developed an F₁₁ AIL population from an F₁ cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F₁₁ mice were challenged with P.c. 'chabaudi' 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F₂ populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL. | Publication Type: | Journal Article | Source of Publication: | Mammalian Genome, 15(5), p. 390-398 | Publisher: | Springer New York LLC | Place of Publication: | United States of America | ISSN: | 1432-1777 0938-8990 |
Fields of Research (FoR) 2008: | 070201 Animal Breeding | Socio-Economic Objective (SEO) 2008: | 830301 Beef Cattle | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article |
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