Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3243
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dc.contributor.authorBehnke, Jerzy Men
dc.contributor.authorIraqi, Fuad Aen
dc.contributor.authorMugambi, John Men
dc.contributor.authorClifford, Simonen
dc.contributor.authorNagda, Sonalen
dc.contributor.authorWakelin, Dereken
dc.contributor.authorKemp, Stephen Jen
dc.contributor.authorLeyden Baker, Ren
dc.contributor.authorGibson, John Paulen
dc.date.accessioned2009-11-23T15:37:00Z
dc.date.issued2006en
dc.identifier.citationMammalian Genome, 17(6), p. 584-597en
dc.identifier.issn0938-8990en
dc.identifier.urihttps://hdl.handle.net/1959.11/3243en
dc.description.abstractFine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F₆/F₇ offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total worm count in week 6). Fecal egg counts were recorded at weeks 2, 4, and 6, and the average was also analyzed. Blood packed cell volume in weeks 3 and 6 and five immunological traits (mucosal mast cell protease 1, granuloma score, IgG1 against adult worm, IgG1, and IgE to L4 antigen) were also recorded. On Chromosome 1 single-trait analyses identified a QTL with effects on eight traits located at about 24 cM on the F₂ mouse genome database (MGD) linkage map, with a 95% confidence interval (CI) of 20-32 cM established from a multitrait analysis. On Chromosome 17 a QTL with effects on nine traits was located at about 18 cM on the MGD map (CI 17.9-18.4 cM). Strong candidate genes for the QTL position on Chromosome 1 include genes known to be involved in regulating immune responses and on Chromosome 17 genes within the MHC, notably the Class II molecules and tumor necrosis factor.en
dc.languageenen
dc.publisherSpringer New Yorken
dc.relation.ispartofMammalian Genomeen
dc.titleHigh resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of miceen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s00335-005-0174-0en
dc.subject.keywordsAnimal Breedingen
local.contributor.firstnameJerzy Men
local.contributor.firstnameFuad Aen
local.contributor.firstnameJohn Men
local.contributor.firstnameSimonen
local.contributor.firstnameSonalen
local.contributor.firstnameDereken
local.contributor.firstnameStephen Jen
local.contributor.firstnameRen
local.contributor.firstnameJohn Paulen
local.subject.for2008070201 Animal Breedingen
local.subject.seo2008839999 Animal Production and Animal Primary Products not elsewhere classifieden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjgibson5@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:3843en
local.publisher.placeNew York, USAen
local.format.startpage584en
local.format.endpage597en
local.peerreviewedYesen
local.identifier.volume17en
local.identifier.issue6en
local.contributor.lastnameBehnkeen
local.contributor.lastnameIraqien
local.contributor.lastnameMugambien
local.contributor.lastnameClifforden
local.contributor.lastnameNagdaen
local.contributor.lastnameWakelinen
local.contributor.lastnameKempen
local.contributor.lastnameLeyden Bakeren
local.contributor.lastnameGibsonen
dc.identifier.staffune-id:jgibson5en
local.profile.roleauthoren
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local.identifier.unepublicationidune:3330en
dc.identifier.academiclevelAcademicen
local.title.maintitleHigh resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of miceen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 287<br />Views: 287<br />Downloads: 0en
local.search.authorBehnke, Jerzy Men
local.search.authorIraqi, Fuad Aen
local.search.authorMugambi, John Men
local.search.authorClifford, Simonen
local.search.authorNagda, Sonalen
local.search.authorWakelin, Dereken
local.search.authorKemp, Stephen Jen
local.search.authorLeyden Baker, Ren
local.search.authorGibson, John Paulen
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