Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials

Wood, Gina; Taylor, Emily; Ng, Vanessa; Murrell, Anna; Patil, Aditya; van der Touw, Tom; Sigal, Ronald; Wolden, Mitch; Smart, Neil

doi:10.1136/bjsports-2021-103999

Author(s)

Wood, Gina

Taylor, Emily

Ng, Vanessa

Murrell, Anna

Patil, Aditya

van der Touw, Tom

Sigal, Ronald

Wolden, Mitch

Smart, Neil

Publication Date

2022-09

Abstract

Objectives To estimate the change in the standard lipid profile (SLP) of adults diagnosed with ≥3 metabolic syndrome (MetS) factors following aerobic exercise training (AET)" and to investigate whether study/ intervention covariates are associated with this change. Design Systematic review with univariate meta-analysis and meta-regression. Data sources English language searches of online databases from inception until July 2020. Eligibility criteria (1) Published randomised controlled human trials with study population ≥10 per group" (2) sedentary adults with ≥3 MetS factors but otherwise free of chronic disease, not pregnant/lactating" (3) AET-only intervention with duration ≥12 weeks" and (4) reporting pre–post intervention SLP outcomes. Results Various univariate meta-analyses pooled 48 data sets of 2990 participants. Aerobic exercise training significantly (P<.001) improved all lipids (mmol/L mean difference ranges, 95% CIs): total cholesterol, –0.19 (– 0.26 to –0.12) to –0.29 (−0.36 to –0.21)" triglycerides, −0.17 (–0.19 to –0.14) to –0.18 (−0.24 to –0.13)" high-density lipoprotein-cholesterol (HDL-C), 0.05 (0.03 to 0.07) to 0.10 (0.05 to 0.15)" and low-density lipoprotein-cholesterol (LDL-C), –0.12 (–0.16 to –0.9) to –0.20 (−0.25 to –0.14). Meta-regression showed that intensity may explain change in triglycerides and volume may explain change in HDL-C and LDL-C. Conclusion Aerobic exercise training positively changes the SLP of sedentary and otherwise healthy adults with ≥3 MetS factors. Adjusting AET intervention training variables may increase the effects of AET on triglycerides and HDL-C.

Citation

British Journal of Sports Medicine, v.56, p. 1032-1041

ISSN

1473-0480

0306-3674

Pubmed ID

34193471

Link

https://hdl.handle.net/1959.11/31938

Language

en

Publisher

BMJ Group

Title

Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials

Type of document

Journal Article

Entity Type

Publication

Author(s)	Wood, Gina Taylor, Emily Ng, Vanessa Murrell, Anna Patil, Aditya van der Touw, Tom Sigal, Ronald Wolden, Mitch Smart, Neil
Publication Date	2022-09
Abstract	<p><b>Objectives</b> To estimate the change in the standard lipid profile (SLP) of adults diagnosed with ≥3 metabolic syndrome (MetS) factors following aerobic exercise training (AET)" and to investigate whether study/ intervention covariates are associated with this change.</p> <p><b>Design</b> Systematic review with univariate meta-analysis and meta-regression.</p> <p><b>Data sources</b> English language searches of online databases from inception until July 2020.</p> <p><b>Eligibility criteria</b> (1) Published randomised controlled human trials with study population ≥10 per group" (2) sedentary adults with ≥3 MetS factors but otherwise free of chronic disease, not pregnant/lactating" (3) AET-only intervention with duration ≥12 weeks" and (4) reporting pre–post intervention SLP outcomes.</p> <p><b>Results</b> Various univariate meta-analyses pooled 48 data sets of 2990 participants. Aerobic exercise training significantly (P<.001) improved all lipids (mmol/L mean difference ranges, 95% CIs): total cholesterol, –0.19 (– 0.26 to –0.12) to –0.29 (−0.36 to –0.21)" triglycerides, −0.17 (–0.19 to –0.14) to –0.18 (−0.24 to –0.13)" high-density lipoprotein-cholesterol (HDL-C), 0.05 (0.03 to 0.07) to 0.10 (0.05 to 0.15)" and low-density lipoprotein-cholesterol (LDL-C), –0.12 (–0.16 to –0.9) to –0.20 (−0.25 to –0.14). Meta-regression showed that intensity may explain change in triglycerides and volume may explain change in HDL-C and LDL-C.</p> <p><b>Conclusion</b> Aerobic exercise training positively changes the SLP of sedentary and otherwise healthy adults with ≥3 MetS factors. Adjusting AET intervention training variables may increase the effects of AET on triglycerides and HDL-C.</p>
Citation	British Journal of Sports Medicine, v.56, p. 1032-1041
ISSN	1473-0480 0306-3674
Pubmed ID	34193471
Link	https://hdl.handle.net/1959.11/31938
Language	en
Publisher	BMJ Group
Title	Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials
Type of document	Journal Article
Entity Type	Publication

Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials

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