Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/31338
Title: Using imputed whole-genome sequence data to improve the accuracy of genomic prediction for parasite resistance in Australian sheep
Contributor(s): Al Kalaldeh, Mohammad  (author)orcid ; Gibson, John  (author)orcid ; Duijvesteijn, Naomi  (author); Daetwyler, Hans D (author); MacLeod, Iona (author); Moghaddar, Nasir  (author)orcid ; Hong Lee, Sang (author); van der Werf, Julius H J  (author)orcid 
Publication Date: 2019-06-26
Open Access: Yes
DOI: 10.1186/s12711-019-0476-4
Handle Link: https://hdl.handle.net/1959.11/31338
Abstract: 

Background: This study aimed at (1) comparing the accuracies of genomic prediction for parasite resistance in sheep based on whole-genome sequence (WGS) data to those based on 50k and high-density (HD) single nucleotide polymorphism (SNP) panels; (2) investigating whether the use of variants within quantitative trait loci (QTL) regions that were selected from regional heritability mapping (RHM) in an independent dataset improved the accuracy more than variants selected from genome-wide association studies (GWAS); and (3) comparing the prediction accuracies between variants selected from WGS data to variants selected from the HD SNP panel.

Results: The accuracy of genomic prediction improved marginally from 0.16 ± 0.02 and 0.18 ± 0.01 when using all the variants from 50k and HD genotypes, respectively, to 0.19 ± 0.01 when using all the variants from WGS data. Fitting a GRM from the selected variants alongside a GRM from the 50k SNP genotypes improved the prediction accuracy substantially compared to fitting the 50k SNP genotypes alone. The gain in prediction accuracy was slightly more pronounced when variants were selected from WGS data compared to when variants were selected from the HD panel. When sequence variants that passed the GWAS -log10(p value) threshold of 3 across the entire genome were selected, the prediction accuracy improved by 5% (up to 0.21 ± 0.01), whereas when selection was limited to sequence variants that passed the same GWAS −log10(p value) threshold of 3 in regions identified by RHM, the accuracy improved by 9% (up to 0.25 ± 0.01).

Conclusions: Our results show that through careful selection of sequence variants from the QTL regions, the accuracy of genomic prediction for parasite resistance in sheep can be improved. These findings have important implications for genomic prediction in sheep.

Publication Type: Journal Article
Source of Publication: Genetics Selection Evolution, v.51, p. 1-13
Publisher: BioMed Central Ltd
Place of Publication: United Kingdom
ISSN: 1297-9686
0999-193X
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
Socio-Economic Objective (SEO) 2020: 100412 Sheep for meat
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

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