Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3077
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dc.contributor.authorWestman, Wendyen
dc.contributor.authorGeiser, Fritzen
dc.date.accessioned2009-11-16T16:59:00Z
dc.date.issued2004en
dc.identifier.citationJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, 174(1), p. 49-57en
dc.identifier.issn0174-1578en
dc.identifier.urihttps://hdl.handle.net/1959.11/3077en
dc.description.abstractThe physiological signal for torpor initiation appears to be related to fuel availability. Studies on metabolic fuel inhibition in placental heterotherms show that glucose deprivation via the inhibitor 2-deoxy-D-glucose (2DG) initiates a torpor-like state, whereas fatty acid deprivation via mercaptoacetate (MA) does not. As previous studies using inhibitors were limited to quantifying body temperature in placentals, we investigated whether inhibition of glucose or fatty acids for cellular oxidation induces torpor in the marsupial hibernator 'Cercartetus nanus', and how the response of metabolic rate is related to body temperature. Glucoprivation initiated a torpor-like state in 'C. nanus', but animals had much higher minimum body temperatures and metabolic rates than those of torpid food-deprived animals and arousal rates were slower. Moreover, 2DG-treated animals were thermoregulating at ambient temperatures of 20 and 12°C, whereas food-deprived torpid animals were thermo-conforming. We suggest that glucoprivation reduces the hypothalamic body temperature set point, but only by about 8°C rather than the approximately 28°C during natural torpor. Reduced fatty acid availability via MA also induced a torpor-like state in some 'C. nanus', with physiological variables that did not differ from those of torpid food-deprived animals. We conclude that reduced glucose availability forms only part of the physiological trigger for torpor initiation in 'C. nanus'. Reduced fatty acid availability, unlike for placental heterotherms, may be an important cue for torpor initiation in 'C. nanus', perhaps because marsupials lack functional brown adipose tissueen
dc.languageenen
dc.publisherSpringer-Verlagen
dc.relation.ispartofJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiologyen
dc.titleThe effect of metabolic fuel availability on thermoregulation and torpor in a marsupial hibernatoren
dc.typeJournal Articleen
dc.identifier.doi10.1007/s00360-003-0388-yen
dc.subject.keywordsComparative Physiologyen
local.contributor.firstnameWendyen
local.contributor.firstnameFritzen
local.subject.for2008060604 Comparative Physiologyen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailfgeiser@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:1421en
local.publisher.placeBerlin/Heidelberg, Germanyen
local.format.startpage49en
local.format.endpage57en
local.peerreviewedYesen
local.identifier.volume174en
local.identifier.issue1en
local.contributor.lastnameWestmanen
local.contributor.lastnameGeiseren
dc.identifier.staffune-id:fgeiseren
local.profile.orcid0000-0001-7621-5049en
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:3160en
dc.identifier.academiclevelAcademicen
local.title.maintitleThe effect of metabolic fuel availability on thermoregulation and torpor in a marsupial hibernatoren
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 56<br />Views: 69<br />Downloads: 0en
local.search.authorWestman, Wendyen
local.search.authorGeiser, Fritzen
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