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Title: Effect of low- and high-protein maternal diets during gestation on reproductive outcomes in the rat: a systematic review and meta-analysis
Contributor(s): Ajuogu, Peter K (author); Wolden, Mitchell (author); McFarlane, James R  (author)orcid ; Hart, Robert A  (author)orcid ; Carlson, Debra J (author); Van der Touw, Tom  (author); Smart, Neil A  (author)orcid 
Publication Date: 2020-01-30
Early Online Version: 2019-12-19
DOI: 10.1093/jas/skz380
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Abstract: Studies with animal models have consistently demonstrated adverse health outcomes in offspring born following nutritional manipulation during gestation. However, the effects of gestational dietary protein modification on reproductive outcomes at birth are less clear. We, therefore, conducted a systematic review and meta-analysis of controlled trials to determine whether high- or low-protein diets are associated with altered reproductive outcomes in a commonly studied species, the rat. Included studies were identified through a systematic search using electronic databases and manual literature review to identify randomized studies published between June 1972 and March 2019. Thirty-two studies were identified and used to analyze the effects of low- and high-protein gestational diets on litter size, litter weight, gestational weight gain, and gestational feed intake. The results indicate that low-protein diets significantly reduced litter weight (P < 0.00001) and gestational weight gain (P < 0.0006), but did not influence litter size (P = 0.62) or gestational feed intake (P = 0.25). In contrast, high-protein diets were found to reduce gestational feed intake (P = 0.004) but did not influence litter size (P = 0.56), litter weight (P = 0.22), or gestational weight gain (P = 0.35). The results suggest that low but not high-protein gestational diets alter reproductive outcomes at birth in rats.
Publication Type: Journal Article
Source of Publication: Journal of Animal Science, 98(1), p. 1-9
Publisher: American Society of Animal Science
Place of Publication: United States of America
ISSN: 1525-3163
Fields of Research (FoR) 2008: 070204 Animal Nutrition
070206 Animal Reproduction
119999 Medical and Health Sciences not elsewhere classified
Fields of Research (FoR) 2020: 300303 Animal nutrition
300305 Animal reproduction and breeding
Socio-Economic Objective (SEO) 2008: 839999 Animal Production and Animal Primary Products not elsewhere classified
920114 Reproductive System and Disorders
920411 Nutrition
Socio-Economic Objective (SEO) 2020: 200410 Nutrition
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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