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Title: The effect of dietary protein intake on factors associated with male infertility: A systematic literature review and meta-analysis of animal clinical trials in rats
Contributor(s): Ajuogu, Peter Kelechi (author); Al-Aqbi, Mohammed A K  (author); Hart, Robert A  (author)orcid ; Wolden, Mitchell (author); Smart, Neil A  (author)orcid ; McFarlane, James R  (author)orcid 
Publication Date: 2020-03-01
Early Online Version: 2020-01-28
DOI: 10.1177/0260106019900731
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Abstract: Background: Studies have shown that the amount of protein in the diet affects the hypothalamic-pituitary-testis axis and sub-optimal quantity reduces male fertility potential in both animals and humans. However, individual research reports on the factors associated with male infertility are collectively uncharacterized. Aim: We systematically reviewed, and meta-analysed animal (rats) studies on the effect of low protein diet on factors associated with male infertility. Methods: PubMed Central, EMBASE and Scopus databases were searched from inception to 30 March 2019 for the study concepts and related keywords in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Data on the outcome measures were extracted and pooled across trials using random-effects model and expressed as mean differences (MD) at a 95% confidence interval (CI). Results: Twelve trials identified from 3327 studies, met our inclusion criteria in the comparison of a low protein diet (2–10% protein) vs control protein diet (17–23% protein). The results showed that a low protein diet caused a significant reduction in the body weight (P = 0.0001) testis weight (P = 0.0001), seminal vesicle weight (P = 0.0003), epididymis weight P = 0.02), serum testosterone (P = 0.001) and follicle-stimulating hormone (FSH) concentrations (P = 0.04) compared with the control treatments. No effect on luteinizing hormone (LH) plasma concentration (P = 0.13) was observed. Conclusion: This study revealed that low protein diet caused significant reductions in body weight, testis, epididymis and seminal vesicle weights, serum testosterone and FSH concentration in rats. We infer that sub-optimal protein consumption reduces the gonadal and endocrine function, and consequently male infertility.
Publication Type: Journal Article
Source of Publication: Nutrition and Health, 26(1), p. 53-64
Publisher: Sage Publications Ltd
Place of Publication: United Kingdom
ISSN: 2047-945X
Fields of Research (FoR) 2008: 070204 Animal Nutrition
070206 Animal Reproduction
119999 Medical and Health Sciences not elsewhere classified
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
300303 Animal nutrition
Socio-Economic Objective (SEO) 2008: 839999 Animal Production and Animal Primary Products not elsewhere classified
920114 Reproductive System and Disorders
920411 Nutrition
Socio-Economic Objective (SEO) 2020: 200410 Nutrition
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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