Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/30162
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ajuogu, Peter K | en |
dc.contributor.author | Al-Aqbi, Mohammed A K | en |
dc.contributor.author | Hart, Robert A | en |
dc.contributor.author | McFarlane, James R | en |
dc.contributor.author | Smart, Neil A | en |
dc.date.accessioned | 2021-03-04T05:14:14Z | - |
dc.date.available | 2021-03-04T05:14:14Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | Journal of Animal Physiology and Animal Nutrition, 105(1), p. 157-166 | en |
dc.identifier.issn | 1439-0396 | en |
dc.identifier.issn | 0931-2439 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/30162 | - |
dc.description.abstract | Research indicates that some adult diseases including reproductive pathologies are programmed in utero during foetal development. In particular, maternal low dietary protein, during the most critical developmental periods of male foetal development, may have a detrimental impact on male fertility through direct and epigenetic mechanisms. The aim of our study was to evaluate the impact of a gestational low protein diet on fertility markers in male offspring in rats through a systematic review and meta‐analysis. A systematic search using PubMed, and EMBASE databases was performed and two investigators independently screened the 1,703 prospective articles. Eleven articles met the eligibility criteria. Outcome measures were pooled using random‐effects models and expressed as mean differences (MDs) at 95% CIs for each study. The results reveal significant reduction in testis weight (MD (mean difference) −0.08 g; −0.12, −0.42; <i>p</i> = .0001), epididymal sperm count (MD −35.34 × 10<sup>6</sup> cells; −52.15, −18.53; <i>p</i> = .0001), number of Sertoli cells (MD −7.27 × 10<sup>6</sup> (−13.92, −0.62; <i>p</i> = .03), testosterone (T) concentration (MD −0.29 ng/ml; −0.48, −0.09; <i>p</i> = .004) and luteinising hormone (LH) concentration (MD of −0.24 ng/ml; −0.45, 0.04; <i>p</i> = .02) in comparison with controls. In contrast, follicle‐stimulating hormone (FSH) concentration (MD of 0.07 ng/ml; −0.16, 0.29; <i>p</i> = .56) was not significantly different from controls. We conclude that low gestational dietary protein maternal intake potentially negatively impacts fertility in male progeny later in life. The mechanisms of action responsible for these phenomena remain unclear. | en |
dc.language | en | en |
dc.publisher | Wiley-Blackwell Verlag GmbH | en |
dc.relation.ispartof | Journal of Animal Physiology and Animal Nutrition | en |
dc.title | A low protein maternal diet during gestation has negative effects on male fertility markers in rats - A Systematic Review and Meta-analysis | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1111/jpn.13411 | en |
dc.identifier.pmid | 32654274 | en |
local.contributor.firstname | Peter K | en |
local.contributor.firstname | Mohammed A K | en |
local.contributor.firstname | Robert A | en |
local.contributor.firstname | James R | en |
local.contributor.firstname | Neil A | en |
local.subject.for2008 | 070204 Animal Nutrition | en |
local.subject.for2008 | 070206 Animal Reproduction | en |
local.subject.for2008 | 119999 Medical and Health Sciences not elsewhere classified | en |
local.subject.seo2008 | 839999 Animal Production and Animal Primary Products not elsewhere classified | en |
local.subject.seo2008 | 920114 Reproductive System and Disorders | en |
local.subject.seo2008 | 920411 Nutrition | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | pajuogu2@une.edu.au | en |
local.profile.email | malaqbi3@une.edu.au | en |
local.profile.email | rhart7@une.edu.au | en |
local.profile.email | jmcfarla@une.edu.au | en |
local.profile.email | nsmart2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | Germany | en |
local.format.startpage | 157 | en |
local.format.endpage | 166 | en |
local.identifier.scopusid | 85087737284 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 105 | en |
local.identifier.issue | 1 | en |
local.contributor.lastname | Ajuogu | en |
local.contributor.lastname | Al-Aqbi | en |
local.contributor.lastname | Hart | en |
local.contributor.lastname | McFarlane | en |
local.contributor.lastname | Smart | en |
dc.identifier.staff | une-id:pajuogu2 | en |
dc.identifier.staff | une-id:malaqbi3 | en |
dc.identifier.staff | une-id:rhart7 | en |
dc.identifier.staff | une-id:jmcfarla | en |
dc.identifier.staff | une-id:nsmart2 | en |
local.profile.orcid | 0000-0002-5898-831X | en |
local.profile.orcid | 0000-0003-4429-5384 | en |
local.profile.orcid | 0000-0002-8290-6409 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/30162 | en |
local.date.onlineversion | 2020-07-12 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | A low protein maternal diet during gestation has negative effects on male fertility markers in rats - A Systematic Review and Meta-analysis | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Ajuogu, Peter K | en |
local.search.author | Al-Aqbi, Mohammed A K | en |
local.search.author | Hart, Robert A | en |
local.search.author | McFarlane, James R | en |
local.search.author | Smart, Neil A | en |
local.uneassociation | Yes | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000547273300001 | en |
local.year.available | 2020 | en |
local.year.published | 2021 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/05fdc1fe-0a31-470c-b0e0-2787040b3b8a | en |
local.subject.for2020 | 300303 Animal nutrition | en |
local.subject.for2020 | 300305 Animal reproduction and breeding | en |
local.subject.seo2020 | 200410 Nutrition | en |
dc.notification.token | 140b9217-4152-4202-a14c-4d5b14d92259 | en |
local.codeupdate.date | 2022-02-11T11:33:40.172 | en |
local.codeupdate.eperson | nsmart2@une.edu.au | en |
local.codeupdate.finalised | true | en |
local.original.for2020 | 300303 Animal nutrition | en |
local.original.for2020 | undefined | en |
local.original.for2020 | 300305 Animal reproduction and breeding | en |
local.original.seo2020 | undefined | en |
local.original.seo2020 | undefined | en |
local.original.seo2020 | 200410 Nutrition | en |
Appears in Collections: | Journal Article School of Science and Technology |
Files in This Item:
File | Size | Format |
---|
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.