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Title: A low protein maternal diet during gestation has negative effects on male fertility markers in rats - A Systematic Review and Meta-analysis
Contributor(s): Ajuogu, Peter K  (author); Al-Aqbi, Mohammed A K  (author); Hart, Robert A  (author)orcid ; McFarlane, James R  (author)orcid ; Smart, Neil A  (author)orcid 
Publication Date: 2021-01
Early Online Version: 2020-07-12
DOI: 10.1111/jpn.13411
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Abstract: Research indicates that some adult diseases including reproductive pathologies are programmed in utero during foetal development. In particular, maternal low dietary protein, during the most critical developmental periods of male foetal development, may have a detrimental impact on male fertility through direct and epigenetic mechanisms. The aim of our study was to evaluate the impact of a gestational low protein diet on fertility markers in male offspring in rats through a systematic review and meta‐analysis. A systematic search using PubMed, and EMBASE databases was performed and two investigators independently screened the 1,703 prospective articles. Eleven articles met the eligibility criteria. Outcome measures were pooled using random‐effects models and expressed as mean differences (MDs) at 95% CIs for each study. The results reveal significant reduction in testis weight (MD (mean difference) −0.08 g; −0.12, −0.42; p = .0001), epididymal sperm count (MD −35.34 × 106 cells; −52.15, −18.53; p = .0001), number of Sertoli cells (MD −7.27 × 106 (−13.92, −0.62; p = .03), testosterone (T) concentration (MD −0.29 ng/ml; −0.48, −0.09; p = .004) and luteinising hormone (LH) concentration (MD of −0.24 ng/ml; −0.45, 0.04; p = .02) in comparison with controls. In contrast, follicle‐stimulating hormone (FSH) concentration (MD of 0.07 ng/ml; −0.16, 0.29; p = .56) was not significantly different from controls. We conclude that low gestational dietary protein maternal intake potentially negatively impacts fertility in male progeny later in life. The mechanisms of action responsible for these phenomena remain unclear.
Publication Type: Journal Article
Source of Publication: Journal of Animal Physiology and Animal Nutrition, 105(1), p. 157-166
Publisher: Wiley-Blackwell Verlag GmbH
Place of Publication: Germany
ISSN: 1439-0396
Fields of Research (FoR) 2008: 070204 Animal Nutrition
070206 Animal Reproduction
119999 Medical and Health Sciences not elsewhere classified
Fields of Research (FoR) 2020: 300303 Animal nutrition
300305 Animal reproduction and breeding
Socio-Economic Objective (SEO) 2008: 839999 Animal Production and Animal Primary Products not elsewhere classified
920114 Reproductive System and Disorders
920411 Nutrition
Socio-Economic Objective (SEO) 2020: 200410 Nutrition
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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