Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/298
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dc.contributor.authorBrown, RFen
dc.contributor.authorTennant, CCen
dc.contributor.authorSharrock, Men
dc.contributor.authorHodgkinson, Sen
dc.contributor.authorDunn, SMen
dc.contributor.authorPollard, JDen
dc.date.accessioned2008-05-13T11:44:00Z
dc.date.issued2006en
dc.identifier.citationMultiple Sclerosis, 12(4), p. 453-464en
dc.identifier.issn1352-4585en
dc.identifier.urihttps://hdl.handle.net/1959.11/298en
dc.description.abstractOBJECTIVE: The aim of this two-year prospective study was to examine the relationship between multiple aspects of life-event stress and relapse in multiple sclerosis (MS) patients.BACKGROUND: Few studies have defined the critical features of this life-event stress; for example, stressor duration, frequency, severity, disease-dependency, valency, or stressor constructs, such as the propensity to cause emotional distress/threat or the frustration of life goals.METHODS: 101 consecutive participants with MS were recruited from two MS clinics in Sydney, Australia. Stressful life events were assessed at study-entry and at three-monthly intervals for two years. Patient-reported relapses were recorded and corroborated by neurologists or evaluated against accepted relapse criteria.RESULTS: Acute events, but not chronic difficulties (CDs), predicted relapse occurrence: acute stressor frequency counts predicted greater relapse risk, along with low disability score (EDSS) and being male. We also confirmed the bi-directional stress-illness hypothesis: stressors predicted relapse, and relapse separately predicted stressors.CONCLUSIONS: Life-event stress impacts to a small degree on MS relapse. The number and not the severity of acute stressors are most important; chronic stressors do not predict later relapse. Males and those with early stage disease are also at greater risk of relapse. MS patients should be encouraged to reduce acute stressors during times of high stress, and feel reassured that disease-related chronic stressors do not increase their relapse risk.en
dc.languageenen
dc.publisherSage Publicationsen
dc.relation.ispartofMultiple Sclerosisen
dc.titleRelationship between stress and relapse in multiple sclerosis: part 1: Important featuresen
dc.typeJournal Articleen
dc.identifier.doi10.1191/1352458506ms1295oaen
dc.subject.keywordsHealth, Clinical and Counselling Psychologyen
local.contributor.firstnameRFen
local.contributor.firstnameCCen
local.contributor.firstnameMen
local.contributor.firstnameSen
local.contributor.firstnameSMen
local.contributor.firstnameJDen
local.subject.for2008170106 Health, Clinical and Counselling Psychologyen
local.subject.seo730104 Nervous system and disordersen
local.profile.schoolSchool of Psychology and Behavioural Scienceen
local.profile.emailrbrown34@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:3209en
local.publisher.placeUnited Kingdomen
local.format.startpage453en
local.format.endpage464en
local.peerreviewedYesen
local.identifier.volume12en
local.identifier.issue4en
local.title.subtitlepart 1: Important featuresen
local.contributor.lastnameBrownen
local.contributor.lastnameTennanten
local.contributor.lastnameSharrocken
local.contributor.lastnameHodgkinsonen
local.contributor.lastnameDunnen
local.contributor.lastnamePollarden
dc.identifier.staffune-id:rbrown34en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:300en
dc.identifier.academiclevelAcademicen
local.title.maintitleRelationship between stress and relapse in multiple sclerosisen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 177<br />Views: 177<br />Downloads: 0en
local.search.authorBrown, RFen
local.search.authorTennant, CCen
local.search.authorSharrock, Men
local.search.authorHodgkinson, Sen
local.search.authorDunn, SMen
local.search.authorPollard, JDen
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