Author(s) |
Raju, Rekha
Merl, Theresa
Adam, Madeleine K
Staykov, Emiliyan
Ben, Robert N
Bryant, Gary
Wilkinson, Brendan L
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Publication Date |
2019-08-14
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Abstract |
A series of eight <i>n</i>-octyl (thio)glycosides (<b>1α, β–4α, β</b>) with D-glucose or D-galactose-configured head groups and varying anomeric configuration were synthesized and evaluated for glass transition behaviour, membrane permeability, and ice recrystallization inhibition (IRI) activity. Of these, <i>n</i>-octyl β-D-glucopyranoside (<b>2β</b>) exhibited a high glass transition temperatures (<i>T<sub>g</sub></i>), both as a neat sample and 20 wt-% aqueous solution. Membrane permeability studies of this compound revealed cellular uptake to concentrations relevant to the inhibition of intracellular ice formation, thus presenting a promising lead candidate for further biophysical and cryopreservation studies. Compounds were also evaluated as ice recrystallization inhibitors; however, no detectable activity was observed for the newly tested compounds.
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Citation |
Australian Journal of Chemistry, 72(8), p. 637-643
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ISSN |
1445-0038
0004-9425
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Link | |
Publisher |
CSIRO Publishing
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Title |
n-Octyl (Thio)glycosides as Potential Cryoprotectants: Glass Transition Behaviour, Membrane Permeability, and Ice Recrystallization Inhibition Studies
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Type of document |
Journal Article
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Entity Type |
Publication
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