Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/29686
Title: Postural sway correlates with cognition and quality of life in Parkinson's disease
Contributor(s): Apthorp, Deborah  (author)orcid ; Smith, Alex (author); IIschner, Susanne (author); Vlieger, Robin (author); Das, Chandi (author); Lueck, Christian J (author); Looi, Jeffrey C L (author)
Publication Date: 2020-11
Early Online Version: 2020-11-05
Open Access: Yes
DOI: 10.1136/bmjno-2020-000086
Handle Link: https://hdl.handle.net/1959.11/29686
Abstract: Background The severity of Parkinson’s disease (PD) is difficult to assess objectively owing to the lack of a robust biological marker of underlying disease status, with consequent implications for diagnosis, treatment and prognosis. The current standard tool is the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), but this is hampered by variability between observers and within subjects. Postural sway has been shown to correlate with complex brain functioning in other conditions. This study aimed to investigate the relationship between postural sway, MDS-UPDRS and other non-motor measures of disease severity in patients with PD.
Method 25 patients with PD and 18 age-matched controls participated in the study. All participants underwent assessment of postural sway using a force plate, with eyes open and closed. In addition, participants underwent tests of cognition and quality of life: Montreal Cognitive Assessment (MoCA), Neuropsychiatry Unit Cognitive Assessment (NUCOG) and, for the patients, the Parkinson’s Disease Questionnaire (PDQ-39–1), and assessment of clinical status using the motor component of the MDS-UPDRS.
Results Patients swayed significantly more than controls. This was most obvious in the eyes-closed condition. Sway path length showed strong correlations with PDQ-39–1, MoCA and the verbal fluency component of the NUCOG, and, to a lesser degree, with the UPDRS-III in patients with PD.
Conclusion These results suggest that motor and non-motor symptoms of PD are associated in patients, and, in particular, that postural sway shows potential as a possible measure of underlying disease status in PD, either alone or in combination with other measures.
Publication Type: Journal Article
Source of Publication: BMJ Neurology Open, 2(2), p. 1-7
Publisher: BMJ Group
Place of Publication: United KIngdom
ISSN: 2632-6140
Fields of Research (FoR) 2008: 170102 Developmental Psychology and Ageing
110999 Neurosciences not elsewhere classified
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Fields of Research (FoR) 2020: 520302 Clinical psychology
Socio-Economic Objective (SEO) 2008: 920112 Neurodegenerative Disorders Related to Ageing
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Psychology

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