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https://hdl.handle.net/1959.11/29664
Title: | GDF15, an update of the physiological and pathological roles it plays: a review | Contributor(s): | Assadi, Artin (author); Zahabi, Azadeh (author); Hart, Robert A (author) | Publication Date: | 2020-11 | Early Online Version: | 2020-09-16 | DOI: | 10.1007/s00424-020-02459-1 | Handle Link: | https://hdl.handle.net/1959.11/29664 | Abstract: | Growth differentiation factor 15 (GDF15) is a peptide hormone, and a divergent member of the transforming growth factor beta (TGFβ) superfamily. In normal physiology, GDF15 is expressed in multiple tissues at a low concentration. GDF15 is overexpressed during and following many pathological conditions such as tissue injury and inflammation in order to play a protective role. However, GDF15 appears to promote tumour growth in the later stages of malignant cancer. The recently identified endogenous receptor for GDF15, GDNF family receptor a-like (GFRAL), has allowed elucidation of a physiological pathway in which GDF15 regulates energy homeostasis and body weight, primarily via appetite suppression. The anorectic effect of GDF15 provides some therapeutic potential in management of cancer-related anorexia/cachexia and obesity. Despite the identification of GFRAL as a GDF15 receptor, there appears to be other signalling mechanisms utilized by GDF15 that further increase the possibility of development of therapeutic treatments, should these pathways be fully characterized. In this review, GDF15 function in both physiological and pathological conditions in various tissues will be discussed. | Publication Type: | Journal Article | Source of Publication: | Pflügers Archiv: European Journal of Physiology, 472(11), p. 1535-1546 | Publisher: | Springer | Place of Publication: | Germany | ISSN: | 1432-2013 0031-6768 |
Fields of Research (FoR) 2008: | 119999 Medical and Health Sciences not elsewhere classified 110306 Endocrinology |
Fields of Research (FoR) 2020: | 320803 Systems physiology | Socio-Economic Objective (SEO) 2008: | 920106 Endocrine Organs and Diseases (excl. Diabetes) | Socio-Economic Objective (SEO) 2020: | 200104 Prevention of human diseases and conditions | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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