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|Title:||Propagation-Based Phase-Contrast CT of the Breast Demonstrates Higher Quality Than Conventional Absorption-Based CT Even at Lower Radiation Dose||Contributor(s):||Tavakoli Taba, Seyedamir (author); Arhatari, Benedicta D (author); Nesterets, Yakov I (author); Gadomkar, Ziba (author); Mayo, Sheridan C (author); Thompson, Darren (author); Fox, Jane (author); Kumar, Beena (author); Prodanovic, Zdenka (author); Hausermann, Daniel (author); Maksimenko, Anton (author); Hall, Christopher (author); Dimmock, Matthew (author); Pavlov, Konstantin M (author) ; Lockie, Darren (author); Gity, Masoumeh (author); Peele, Andrew (author); Quiney, Harry M (author); Lewis, Sarah (author); Gureyev, Timur E (author) ; Brennan, Patrick C (author)||Early Online Version:||2020-02-05||DOI:||10.1016/j.acra.2020.01.009||Handle Link:||https://hdl.handle.net/1959.11/29453||Abstract:||Rationale and Objectives: Propagation-based phase-contrast CT (PB-CT) is an advanced X-ray imaging technology that exploits both refraction and absorption of the transmitted X-ray beam. This study was aimed at optimizing the experimental conditions of PB-CT for breast cancer imaging and examined its performance relative to conventional absorption-based CT (AB-CT) in terms of image quality and radiation dose.
Materials and Methods: Surgically excised breast mastectomy specimens (n = 12) were scanned using both PB-CT and AB-CT techniques under varying imaging conditions. To evaluate the radiological image quality, visual grading characteristics (VGC) analysis was used in which 11 breast specialist radiologists compared the overall image quality of PB-CT images with respect to the corresponding AB-CT images. The area under the VGC curve was calculated to measure the differences between PB-CT and AB-CT images.
Results: The highest radiological quality was obtained for PB-CT images using a 32 keV energy X-ray beam and by applying the Homogeneous Transport of Intensity Equation phase retrieval with the value of its parameter γ set to one-half of the theoretically optimal value for the given materials. Using these optimized conditions, the image quality of PB-CT images obtained at 4 mGy and 2 mGy mean glandular dose was significantly higher than AB-CT images at 4 mGy (AUC VGC = 0.901, p = 0.001 and AUC VGC = 0.819, p = 0.011, respectively).
Conclusion: PB-CT achieves a higher radiological image quality compared to AB-CT even at a considerably lower mean glandular dose. Successful translation of the PB-CT technique for breast cancer imaging can potentially result in improved breast cancer diagnosis.
|Publication Type:||Journal Article||Source of Publication:||Academic Radiology, p. 1-7||Publisher:||Elsevier BV||Place of Publication:||The Netherlands||Field of Research (FOR):||029903 Medical Physics||Socio-Economic Objective (SEO):||920102 Cancer and Related Disorders||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal|
|Appears in Collections:||Journal Article|
School of Science and Technology
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