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Title: Comparison of propagation-based CT using synchrotron radiation and conventional cone-beam CT for breast imaging
Contributor(s): Tavakoli Taba, Seyedamir (author); Baran, Patrycja (author); Nesterets, Yakov I  (author); Pacile, Serena (author); Wienbeck, Susanne (author); Dullin, Christian (author); Pavlov, Konstantin  (author)orcid ; Maksimenko, Anton (author); Lockie, Darren (author); Mayo, Sheridan C (author); Quiney, Harry M (author); Dreossi, Diego (author); Arfelli, Fulvia (author); Tromba, Giuliana (author); Lewis, Sarah (author); Gureyev, Timur E  (author)orcid ; Brennan, Patrick C (author)
Publication Date: 2020-05
Early Online Version: 2020-01-23
DOI: 10.1007/s00330-019-06567-0
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Abstract: Objectives To evaluate and compare the image quality of propagation-based phase-contrast computed tomography (PB-CT) using synchrotron radiation and conventional cone-beam breast computed tomography (CBBCT) based on various radiological image quality criteria.
Methods Eight excised breast tissue samples of various sizes and containing different lesion types were scanned using PB-CT at a synchrotron facility and using CBBCT at a university-affiliated breast imaging centre. PB-CT scans were performed at two different mean glandular dose (MGD) levels: standard (5.8 mGy) and low (1.5 mGy), for comparison with CBBCT scans at the standard MGD (5.8 mGy). Image quality assessment was carried out using six quality criteria and six independent medical imaging experts in a reading room with mammography workstations. The interobserver agreement between readers was evaluated using intraclass correlation coefficient (ICC), and image quality was compared between the two breast imaging modalities using the area under the visual grading characteristic curve (AUCVGC).
Results Interobserver agreement between the readers showed moderate reliability for five image criteria (ICC: ranging from 0.488 to 0.633) and low reliability for one criterion (image noise) (ICC 0.307). For five image quality criteria (overall quality, perceptible contrast, lesion sharpness, normal tissue interfaces, and calcification visibility), both standard-dose PB-CT images (AUCVGC 0.958 to 1, p ≤ .05) and low dose PB-CT images (AUCVGC 0.785 to 0.834, p ≤ .05) were of significantly higher image quality than standard-dose CBBCT images.
Conclusions Synchrotron-based PB-CT can achieve a significantly higher radiological image quality at a substantially lower radiation dose compared with conventional CBBCT.
Key Points
• PB-CT using synchrotron radiation results in higher image quality than conventional CBBCT for breast imaging.
• PB-CT using synchrotron radiation requires a lower radiation dose than conventional CBBCT for breast imaging.
• PB-CT can help clinicians diagnose patients with breast cancer.
Publication Type: Journal Article
Source of Publication: European Radiology, 30(5), p. 2740-2750
Publisher: Springer
Place of Publication: Germany
ISSN: 1432-1084
Field of Research (FOR): 029904 Synchrotrons; Accelerators; Instruments and Techniques
029903 Medical Physics
Socio-Economic Objective (SEO): 920102 Cancer and Related Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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