Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies

Title
Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies
Publication Date
2019-09-24
Author(s)
Pacile, S
Dullin, C
Baran, P
Tonutti, M
Perske, C
Fischer, U
Albers, J
Arfelli, F
Dreossi, D
Pavlov, K
( author )
OrcID: https://orcid.org/0000-0002-1756-4406
Email: kpavlov@une.edu.au
UNE Id une-id:kpavlov
Maksimenko, A
Mayo, S C
Nesterets, Y I
Tavakoli Taba, S
Lewis, S
Brennan, P C
Gureyev, T E
( author )
OrcID: https://orcid.org/0000-0002-1103-0649
Email: tgureyev@une.edu.au
UNE Id une-id:tgureyev
Tromba, G
Wienbeck, S
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Nature Publishing Group
Place of publication
United Kingdom
DOI
10.1038/s41598-019-50075-6
UNE publication id
une:1959.11/29450
Abstract
In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.
Link
Citation
Scientific Reports, v.9, p. 1-7
ISSN
2045-2322
Pubmed ID
31551475
Start page
1
End page
7
Rights
Attribution 4.0 International

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