Enlisting plants in the battle for new antibacterial compounds

Title
Enlisting plants in the battle for new antibacterial compounds
Publication Date
2019-11-08
Author(s)
Lyddiard, Dane
Greatrex, Ben W
( author )
OrcID: https://orcid.org/0000-0002-0356-4966
Email: bgreatre@une.edu.au
UNE Id une-id:bgreatre
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
CSIRO Publishing
Place of publication
Australia
DOI
10.1071/MA19050
UNE publication id
une:1959.11/29360
Abstract
A rise in antibacterial drug resistance comes at a time when our once reliable sources of antibacterial natural products, bacteria and fungi, are failing us. The search for new drugs to fight pathogens has led to a range of innovative approaches and includes screening organisms which have developed evolutionary adaptions to prevent bacterial attack. The discovery of antibacterial phytochemicals from plants can be achieved using an activity-guided platform involving biological and chemical pre-screening, compound isolation, structure elucidation, and the direct testing of isolated compounds. Challenges include the clean isolation of natural products, avoiding the rediscovery of known compounds, toxicity, and poor levels of activity.
Link
Citation
Microbiology Australia, 40(4), p. 169-172
ISSN
2201-9189
1324-4272
Start page
169
End page
172
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International

Files:

NameSizeformatDescriptionLink