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Title: Is C-reactive protein elevated in obstructive sleep apnea? a systematic review and meta-analysis
Contributor(s): Van Der Touw, Tom  (author); Andronicos, Nicholas Matthew  (author)orcid ; Smart, Neil  (author)orcid 
Publication Date: 2019
Early Online Version: 2019-04-17
DOI: 10.1080/1354750X.2019.1600025
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Purpose: This study examined whether circulating C-reactive protein (CRP) is elevated in obstructive sleep apnoea (OSA) independent of the confounding effects of comorbidities, smoking, body mass index (BMI), age and gender.

Methods: A systematic review of the literature was performed using PubMed, Embase and Cochrane databases from 1 January 1997 to 1 November 2017 using the key words obstructive sleep apnoea and C-Reactive protein to identify full text English language studies that compared CRP in adult non-smoking OSA participants without comorbidities and adult healthy non-smoking control participants matched for BMI, age and gender. Data from eligible studies were subjected to meta-analysis using RevMan version 5.3.

Results: Five studies (219 OSA participants, 116 controls) met the selection criteria. The total standard mean difference for circulating high sensitivity CRP was 0.61 mg/dL higher in OSA participants than in control participants (confidence interval: 0.38 to 0.84, p < 0.00001), with low between-studies heterogeneity (df = 7, p = 0.16, I2 = 33%) and minimal evidence of publication bias.

Conclusions: CRP levels in non-smoking OSA participants without comorbidities were increased relative to levels in healthy matched non-smoking control participants, suggesting that pharyngeal or systemic inflammatory effects attributable to OSA may elevate CRP.

Publication Type: Journal Article
Source of Publication: Biomarkers, 24(5), p. 429-435
Publisher: Taylor & Francis
Place of Publication: United Kingdom
ISSN: 1366-5804
Fields of Research (FoR) 2008: 110203 Respiratory Diseases
Fields of Research (FoR) 2020: 320803 Systems physiology
320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920115 Respiratory System and Diseases (incl. Asthma)
Socio-Economic Objective (SEO) 2020: 200104 Prevention of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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