Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/29141
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dc.contributor.authorMulder, H Aen
dc.contributor.authorLee, S Hen
dc.contributor.authorClark, Samen
dc.contributor.authorHayes, Ben
dc.contributor.authorvan der Werf, Julius H Jen
dc.date.accessioned2020-07-28T04:14:37Z-
dc.date.available2020-07-28T04:14:37Z-
dc.date.issued2019-
dc.identifier.citationBook of Abstracts of the 70th Annual Meeting of the European Federation of Animal Science, p. 123-123en
dc.identifier.isbn9789086863396en
dc.identifier.isbn9789086868902en
dc.identifier.urihttps://hdl.handle.net/1959.11/29141-
dc.description.abstractDe novo mutations (DNM) create new genetic variance and are an important driver for long-term selection response. We hypothesized that genomic selection without own phenotypes exploits new mutational variance less than pedigree-based BLUP selection. The objectives were to compare GBLUP selection without own phenotype (GBLUP), GBLUP selection with own phenotype (GBLUP_OP) and pedigree-based BLUP selection with own phenotype for 20 generations using Monte Carlo simulation. GBLUP resulted in the lowest genetic variance (24.7% of total genetic variance) and response due to DNM after 20 generations (9.4% of total response). GBLUP_OP had the highest genetic variance due to new DNM (47.8% of total genetic variance) and selection response due to DNM (30% of total response), while BLUP was in between with 27.1% of genetic variance due to DNM and 21.9% of response due to DNM. However, GBLUP_OP caused a rapid decline in total genetic variance, because the genetic variance due to old QTL rapidly eroded. GBLUP had very little selection pressure on DNM and as a consequence, GBLUP had the highest number of DNM with negative effects that were still segregating 10 generations after a DNM arose. Due to the decline in genetic variance for all selection strategies, selection limits are foreseen and these selection limits are lower for GBLUP (11.2 phenotypic SD from the base population mean) and GBLUP_OP (10.7 phenotypic SD) than for BLUP selection (11.8 phenotypic SD). It can be concluded that genomic selection without own phenotypes exploits new mutational variance less than BLUP selection with own phenotypes, it increases the probability of DNM with negative effects and it lowers selection limits. Sustainable breeding strategies should consider optimal ways to exploit DNM.en
dc.languageenen
dc.publisherWageningen Academic Publishersen
dc.relation.ispartofBook of Abstracts of the 70th Annual Meeting of the European Federation of Animal Scienceen
dc.titleGenomic selection without own phenotypes exploits new mutational variance less than BLUP selectionen
dc.typeConference Publicationen
dc.relation.conference70th Annual Meeting of the European Federation of Animal Scienceen
dc.identifier.doi10.3920/978-90-8686-890-2en
local.contributor.firstnameH Aen
local.contributor.firstnameS Hen
local.contributor.firstnameSamen
local.contributor.firstnameBen
local.contributor.firstnameJulius H Jen
local.subject.for2008070201 Animal Breedingen
local.subject.for2008060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)en
local.subject.for2008060408 Genomicsen
local.subject.seo2008830399 Livestock Raising not elsewhere classifieden
local.subject.seo2008830302 Dairy Cattleen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailslee38@une.edu.auen
local.profile.emailsclark37@une.edu.auen
local.profile.emailjvanderw@une.edu.auen
local.output.categoryE3en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.date.conference26th - 30th August, 2019en
local.conference.placeGhent, Belgiumen
local.publisher.placeWageningen, Netherlandsen
local.format.startpage123en
local.format.endpage123en
local.contributor.lastnameMulderen
local.contributor.lastnameLeeen
local.contributor.lastnameClarken
local.contributor.lastnameHayesen
local.contributor.lastnamevan der Werfen
dc.identifier.staffune-id:slee38en
dc.identifier.staffune-id:sclark37en
dc.identifier.staffune-id:jvanderwen
local.profile.orcid0000-0001-8605-1738en
local.profile.orcid0000-0003-2512-1696en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/29141en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleGenomic selection without own phenotypes exploits new mutational variance less than BLUP selectionen
local.output.categorydescriptionE3 Extract of Scholarly Conference Publicationen
local.relation.urlhttps://www.wageningenacademic.com/doi/abs/10.3920/978-90-8686-890-2#page=125en
local.relation.urlhttps://www.cita-aragon.es/sites/default/files/eaap_programme_2019.pdfen
local.relation.urlhttps://meetings.eaap.org/ghent-2019/en
local.conference.detailsen
local.search.authorMulder, H Aen
local.search.authorLee, S Hen
local.search.authorClark, Samen
local.search.authorHayes, Ben
local.search.authorvan der Werf, Julius H Jen
local.uneassociationUnknownen
dc.date.presented2019-
local.atsiresearchNoen
local.conference.venueInternational Convention Centreen
local.sensitive.culturalNoen
local.year.published2019en
local.year.presented2019en
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.for2020310506 Gene mappingen
local.subject.for2020310509 Genomicsen
local.subject.seo2020100402 Dairy cattleen
local.date.start2019-08-26-
local.date.end2019-08-30-
Appears in Collections:Conference Publication
School of Environmental and Rural Science
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