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Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses |
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Association for the Advancement of Animal Breeding and Genetics (AAABG) |
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This simulation study shows a method which makes more efficient use of pedigree and genomic information to increase the chance to detect genetic disorders. We make use of Geneprob, a program which uses segregation analysis to calculate the genotype probabilities of pedigreed animals. The results show that our method, for a trait with a recessive inheritance pattern, is better in the detection of the region of the causative mutation compared to a method which used allele frequencies of cases and controls only. This method can be used across all pedigreed species. |
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Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.23, p. 210-213 |
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