Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses

Author(s)
Duijvesteijn, N
Clark, S A
Kinghorn, B P
van der Werf, J H J
Publication Date
2019
Abstract
This simulation study shows a method which makes more efficient use of pedigree and genomic information to increase the chance to detect genetic disorders. We make use of Geneprob, a program which uses segregation analysis to calculate the genotype probabilities of pedigreed animals. The results show that our method, for a trait with a recessive inheritance pattern, is better in the detection of the region of the causative mutation compared to a method which used allele frequencies of cases and controls only. This method can be used across all pedigreed species.
Citation
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.23, p. 210-213
ISSN
1328-3227
Link
https://hdl.handle.net/1959.11/29017
Language
en
Publisher
Association for the Advancement of Animal Breeding and Genetics (AAABG)
Title
Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses
Type of document
Conference Publication
Entity Type
Publication

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