Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/29017
Title: Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses
Contributor(s): Duijvesteijn, N  (author); Clark, S A  (author)orcid ; Kinghorn, B P  (author); van der Werf, J H J  (author)orcid 
Publication Date: 2019
Open Access: Yes
Handle Link: https://hdl.handle.net/1959.11/29017
Open Access Link: http://www.aaabg.org/aaabghome/fullproc23.phpOpen Access Link
Abstract: This simulation study shows a method which makes more efficient use of pedigree and genomic information to increase the chance to detect genetic disorders. We make use of Geneprob, a program which uses segregation analysis to calculate the genotype probabilities of pedigreed animals. The results show that our method, for a trait with a recessive inheritance pattern, is better in the detection of the region of the causative mutation compared to a method which used allele frequencies of cases and controls only. This method can be used across all pedigreed species.
Publication Type: Conference Publication
Conference Details: AAABG 2019: 23rd Conference of the Association for the Advancement of Animal Breeding and Genetics, Armidale, Australia, 27 October-1 November
Source of Publication: Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.23, p. 210-213
Publisher: Association for the Advancement of Animal Breeding and Genetics (AAABG)
Place of Publication: Armidale, Australia
ISSN: 1328-3227
Fields of Research (FoR) 2008: 070201 Animal Breeding
060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
060408 Genomics
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
310506 Gene mapping
310509 Genomics
Socio-Economic Objective (SEO) 2008: 830310 Sheep - Meat
830311 Sheep - Wool
Socio-Economic Objective (SEO) 2020: 100412 Sheep for meat
100413 Sheep for wool
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Publisher/associated links: http://www.aaabg.org/aaabghome/
Appears in Collections:Conference Publication
School of Environmental and Rural Science

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