Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses

Abstract

This simulation study shows a method which makes more efficient use of pedigree and genomic information to increase the chance to detect genetic disorders. We make use of Geneprob, a program which uses segregation analysis to calculate the genotype probabilities of pedigreed animals. The results show that our method, for a trait with a recessive inheritance pattern, is better in the detection of the region of the causative mutation compared to a method which used allele frequencies of cases and controls only. This method can be used across all pedigreed species.