Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/29017
Title: | Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses | Contributor(s): | Duijvesteijn, N (author); Clark, S A (author)![]() ![]() |
Publication Date: | 2019 | Open Access: | Yes | Handle Link: | https://hdl.handle.net/1959.11/29017 | Open Access Link: | http://www.aaabg.org/aaabghome/fullproc23.php![]() |
Abstract: | This simulation study shows a method which makes more efficient use of pedigree and genomic information to increase the chance to detect genetic disorders. We make use of Geneprob, a program which uses segregation analysis to calculate the genotype probabilities of pedigreed animals. The results show that our method, for a trait with a recessive inheritance pattern, is better in the detection of the region of the causative mutation compared to a method which used allele frequencies of cases and controls only. This method can be used across all pedigreed species. | Publication Type: | Conference Publication | Conference Details: | AAABG 2019: 23rd Conference of the Association for the Advancement of Animal Breeding and Genetics, Armidale, Australia, 27 October-1 November | Source of Publication: | Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.23, p. 210-213 | Publisher: | Association for the Advancement of Animal Breeding and Genetics (AAABG) | Place of Publication: | Armidale, Australia | ISSN: | 1328-3227 | Fields of Research (FoR) 2008: | 070201 Animal Breeding 060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics) 060408 Genomics |
Fields of Research (FoR) 2020: | 300305 Animal reproduction and breeding 310506 Gene mapping 310509 Genomics |
Socio-Economic Objective (SEO) 2008: | 830310 Sheep - Meat 830311 Sheep - Wool |
Socio-Economic Objective (SEO) 2020: | 100412 Sheep for meat 100413 Sheep for wool |
Peer Reviewed: | Yes | HERDC Category Description: | E1 Refereed Scholarly Conference Publication | Publisher/associated links: | http://www.aaabg.org/aaabghome/ |
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Appears in Collections: | Conference Publication School of Environmental and Rural Science |
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