Author(s) |
Duijvesteijn, N
Clark, S A
Kinghorn, B P
van der Werf, J H J
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Publication Date |
2019
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Abstract |
This simulation study shows a method which makes more efficient use of pedigree and genomic information to increase the chance to detect genetic disorders. We make use of Geneprob, a program which uses segregation analysis to calculate the genotype probabilities of pedigreed animals. The results show that our method, for a trait with a recessive inheritance pattern, is better in the detection of the region of the causative mutation compared to a method which used allele frequencies of cases and controls only. This method can be used across all pedigreed species.
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Citation |
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.23, p. 210-213
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ISSN |
1328-3227
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Link | |
Publisher |
Association for the Advancement of Animal Breeding and Genetics (AAABG)
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Title |
Increase of Power and Efficiency to Fine-Map Genetic Defects Using Genotype Probabilities Through Segregation Analyses
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Type of document |
Conference Publication
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Entity Type |
Publication
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