Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/28985
Title: The fate of new mutations: genomic selection exploits new mutation variance to a much smaller degree than traditional selection
Contributor(s): Mulder, H A (author); Lee, S H  (author); Clark, S  (author)orcid ; Hayes, B J (author); van der Werf, J H J  (author)orcid 
Publication Date: 2018
Open Access: Yes
Handle Link: https://hdl.handle.net/1959.11/28985
Open Access Link: http://www.wcgalp.org/proceedings/2018/fate-new-mutations-genomic-selection-exploits-new-mutation-variance-much-smaller
Abstract: New mutations create new genetic variance in populations and contribute to long-term response to selection. We hypothesize that genomic selection exploits new mutational variance much less than traditional selection methods, because new mutations are not in linkage disequilibrium with markers on the current SNP chips, while animals with a favourable mutation have a selective advantage with mass and pedigree-based BLUP selection. We used Monte Carlo simulation using real sequence data to generate the base generation to test this hypothesis. Genomic selection increased response to selection due to old QTL by 33% and 1% in generation 5 and 20 compared to mass selection, respectively, while response to selection from new mutations was 65-85% and 61% lower than with mass selection in generation 5 and 20, respectively. In genomic selection, genetic variance due to old QTL was much faster eroded, while new mutational variance did not increase much, resulting in a ~65% and ~43% lower total genetic variance in generation 20 with genomic selection, compared to mass and pedigree-based BLUP selection. In summary, we showed that genomic selection hardly exploits new mutational variance and erodes genetic variance much faster than mass and BLUP selection. Future research should focus on developing sustainable genomic selection strategies to optimize long-term response to selection, exploiting new mutational variance.
Publication Type: Conference Publication
Conference Details: WCGALP 2018: 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11th - 16th February, 2018
Source of Publication: Proceedings of the World Congress on Genetics Applied to Livestock Production, v.11, p. 1-5
Publisher: Massey University
Place of Publication: Palmerston North, New Zealand
Fields of Research (FoR) 2008: 070201 Animal Breeding
060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
060408 Genomics
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
310506 Gene mapping
310509 Genomics
Socio-Economic Objective (SEO) 2008: 830399 Livestock Raising not elsewhere classified
830302 Dairy Cattle
Socio-Economic Objective (SEO) 2020: 100402 Dairy cattle
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Publisher/associated links: http://www.wcgalp.org/proceedings/2018
Appears in Collections:Conference Publication
School of Environmental and Rural Science

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