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https://hdl.handle.net/1959.11/28982
Title: | Combining information from genome-wide association and multi-tissue gene expression studies to elucidate factors underlying genetic variation for residual feed intake in Australian Angus cattle | Contributor(s): | de las Heras-Saldana, Sara (author) ; Clark, Samuel A (author) ; Duijvesteijn, Naomi (author); Gondro, Cedric (author) ; van der Werf, Julius H J (author) ; Chen, Yizhou (author) | Publication Date: | 2019-12-06 | Open Access: | Yes | DOI: | 10.1186/s12864-019-6270-4 | Handle Link: | https://hdl.handle.net/1959.11/28982 | Abstract: | Background: Genome-wide association studies (GWAS) are extensively used to identify single nucleotide polymorphisms (SNP) underlying the genetic variation of complex traits. However, much uncertainly often still exists about the causal variants and genes at quantitative trait loci (QTL). The aim of this study was to identify QTL associated with residual feed intake (RFI) and genes in these regions whose expression is also associated with this trait. Angus cattle (2190 steers) with RFI records were genotyped and imputed to high density arrays (770 K) and used for a GWAS approach to identify QTL associated with RFI. RNA sequences from 126 Angus divergently selected for RFI were analyzed to identify the genes whose expression was significantly associated this trait with special attention to those genes residing in the QTL regions. | Publication Type: | Journal Article | Source of Publication: | BMC Genomics, 20(1), p. 1-16 | Publisher: | BioMed Central Ltd | Place of Publication: | United Kingdom | ISSN: | 1471-2164 | Fields of Research (FoR) 2008: | 070201 Animal Breeding 060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics) 060408 Genomics |
Fields of Research (FoR) 2020: | 310505 Gene expression (incl. microarray and other genome-wide approaches) 300305 Animal reproduction and breeding |
Socio-Economic Objective (SEO) 2008: | 830301 Beef Cattle | Socio-Economic Objective (SEO) 2020: | 100401 Beef cattle | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Environmental and Rural Science |
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openpublished/CombiningHerasSaldanaClarkDuijvesteijnGondroVanDerWerf2019JournalArticle.pdf | Published version | 1.1 MB | Adobe PDF Download Adobe | View/Open |
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