Design, Statistical and Methodological Considerations: Comorbidity

Author(s)
Thorsteinsson, Einar
Brown, Rhonda
Publication Date
2020
Abstract
Research of disease comorbidity and symptom co-occurrence raises several issues relating to study design and analytical techniques that require careful consideration. In this chapter, we first address methodological issues that are of particular relevance in comorbidity research, including symptom overlap and the resultant double counting of symptoms; the pitfalls and advantages of removing overlapping scale items; and the utility of creating latent variables or ‘symptom groups’. We then discuss the advantages and limitations of employing various study designs in the context of comorbidity research and make recommendations for maximising the scientific rigour of statistical analyses whilst ensuring that ethical standards are met. Finally, we highlight analytical techniques that are relatively novel and/or less commonly utilised in studies of comorbidity, and how these techniques might advance research in this field.
Citation
Comorbidity: Symptoms, Conditions, Behaviour and Treatments, p. 221-239
ISBN
9783030325442
303032544X
9783030325459
3030325458
Link
Language
en
Publisher
Palgrave Macmillan
Edition
1
Title
Design, Statistical and Methodological Considerations: Comorbidity
Type of document
Book Chapter
Entity Type
Publication

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