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Title: Design, Statistical and Methodological Considerations: Comorbidity
Contributor(s): Thorsteinsson, Einar  (author)orcid ; Brown, Rhonda  (author)
Publication Date: 2020
DOI: 10.1007/978-3-030-32545-9_8
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Abstract: Research of disease comorbidity and symptom co-occurrence raises several issues relating to study design and analytical techniques that require careful consideration. In this chapter, we first address methodological issues that are of particular relevance in comorbidity research, including symptom overlap and the resultant double counting of symptoms; the pitfalls and advantages of removing overlapping scale items; and the utility of creating latent variables or ‘symptom groups’. We then discuss the advantages and limitations of employing various study designs in the context of comorbidity research and make recommendations for maximising the scientific rigour of statistical analyses whilst ensuring that ethical standards are met. Finally, we highlight analytical techniques that are relatively novel and/or less commonly utilised in studies of comorbidity, and how these techniques might advance research in this field.
Publication Type: Book Chapter
Source of Publication: Comorbidity: Symptoms, Conditions, Behaviour and Treatments, p. 221-239
Publisher: Palgrave Macmillan
Place of Publication: Cham, Switzerland
ISBN: 9783030325442
Fields of Research (FoR) 2008: 170106 Health, Clinical and Counselling Psychology
111714 Mental Health
Fields of Research (FoR) 2020: 520302 Clinical psychology
Socio-Economic Objective (SEO) 2008: 920410 Mental Health
970117 Expanding Knowledge in Psychology and Cognitive Sciences
Socio-Economic Objective (SEO) 2020: 200409 Mental health
280121 Expanding knowledge in psychology
HERDC Category Description: B1 Chapter in a Scholarly Book
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Editor: Editor(s): Rhonda Brown and Einar Thorsteinsson
Appears in Collections:Book Chapter
School of Psychology

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