Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/28117
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dc.contributor.authorJayasundara, JMKGKen
dc.contributor.authorWalkden-Brown, S Wen
dc.contributor.authorIslam, AFMFen
dc.contributor.authorKatz, M Een
dc.contributor.authorRenz, K Gen
dc.date.accessioned2020-03-04T02:21:08Z-
dc.date.available2020-03-04T02:21:08Z-
dc.date.issued2018-05-
dc.identifier.citationAustralian Veterinary Journal, 96(5), p. 167-175en
dc.identifier.issn1751-0813en
dc.identifier.issn0005-0423en
dc.identifier.urihttps://hdl.handle.net/1959.11/28117-
dc.description.abstractObjective To compare the effects of infectious bursal disease virus (IBDV) infection of commercial meat chickens at 0 and 16 days old (d.o.) and determine if IBDV vRNA is quantifiable in litter and dust samples. <br/> Methods Ross meat chickens (n = 60) were orally infected or not with IBDV at 0 or 16 d.o. Blood and faecal samples were collected longitudinally to 28 days post infection (dpi) from six chickens and tissues collected weekly from three euthanased chickens. Relative bursal weight was recorded postmortem. IBDV antibody titres in sera were measured using ELISA and VCN was determined in tissues, faeces, litter and dust using qRT-PCR. <br/> Results Chickens infected at 16 d.o. had earlier and more severe bursal atrophy, earlier and higher IBDV vRNA load in lymphoidorgans and an earlier and greater antibody response to infection than those infected at 0 d.o. Faecal shedding of IBDV between 2 and 6 dpi was observed in both groups followed by cessation with the 0 d.o. group and re-initiation of shedding at 28 dpi. IBDV was readily detected and quantified in litter and dust samples. <br/> Conclusions The presence of significant maternal antibody (MAb) titres in 0 d.o. chickens provided protection against IBDV replication and bursal atrophy at 7 and 14 days post infection. The reduced titres of MAb present at 16 d.o. did not prevent rapid IBDV replication and early marked bursal atrophy. The observed resistance of 0 d.o. chickens is likely to be a combination of MAb inhibition of IBDV and true age resistance of neonatal chicks. Measurement of IBDV in litter and dust may have research or diagnostic application.en
dc.languageenen
dc.publisherWiley-Blackwell Publishing Ltden
dc.relation.ispartofAustralian Veterinary Journalen
dc.titleTissue distribution, shedding and environmental detection of infectious bursal disease virus genome following infection of meat chickens at two agesen
dc.typeJournal Articleen
dc.identifier.doi10.1111/avj.12691en
dc.identifier.pmid29691850en
local.contributor.firstnameJMKGKen
local.contributor.firstnameS Wen
local.contributor.firstnameAFMFen
local.contributor.firstnameM Een
local.contributor.firstnameK Gen
local.subject.for2008070205 Animal Protection (Pests and Pathogens)en
local.subject.for2008070712 Veterinary Virologyen
local.subject.seo2008830309 Poultryen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailswalkden@une.edu.auen
local.profile.emailfislam2@une.edu.auen
local.profile.emailmkatz@une.edu.auen
local.profile.emailkrenz@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited Kingdomen
local.format.startpage167en
local.format.endpage175en
local.identifier.scopusid85045906585en
local.peerreviewedYesen
local.identifier.volume96en
local.identifier.issue5en
local.contributor.lastnameJayasundaraen
local.contributor.lastnameWalkden-Brownen
local.contributor.lastnameIslamen
local.contributor.lastnameKatzen
local.contributor.lastnameRenzen
dc.identifier.staffune-id:swalkdenen
dc.identifier.staffune-id:fislam2en
dc.identifier.staffune-id:mkatzen
dc.identifier.staffune-id:krenzen
local.profile.orcid0000-0002-0638-5533en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/28117en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleTissue distribution, shedding and environmental detection of infectious bursal disease virus genome following infection of meat chickens at two agesen
local.relation.fundingsourcenoteUniversity of New England IPRS and UNERA scholarshipsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorJayasundara, JMKGKen
local.search.authorWalkden-Brown, S Wen
local.search.authorIslam, AFMFen
local.search.authorKatz, M Een
local.search.authorRenz, K Gen
local.istranslatedNoen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000430805600019en
local.year.published2018en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/04a156ae-8a62-44ed-ba46-0b26d901d0c0en
local.subject.for2020300304 Animal protection (incl. pests and pathogens)en
local.subject.for2020300914 Veterinary virologyen
local.subject.seo2020100411 Poultryen
Appears in Collections:Journal Article
School of Environmental and Rural Science
School of Science and Technology
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