Baran, Patrycja

Mayo, Sheridan

McCormack, Mikkaela

Pacile, Serena

Tromba, Giuliana

Dullin, Christian

Zanconati, Fabrizio

Arfelli, Fulvia

Dreossi, Diego

Fox, Jane

Prodanovic, Zdenka

Cholewa, Marian

Quiney, Harry

Dimmock, Matthew

Nesterets, Yakov

Thompson, Darren

Brennan, Patrick

Gureyev, Timur

2018-12

Histopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained 1.2 μm pixel size images, which were analyzed and compared with corresponding histological sections examined under light microscopy. To evaluate the effect of spatial resolution on breast cancer diagnosis, scans with four different pixel sizes were also performed. Our comparative analysis revealed that high-resolution images can enable, at a near-histological level, detailed architectural assessment of tissue that may permit increased breast cancer diagnostic sensitivity and specificity when compared with current imaging practices. The potential clinical applications of this method are also discussed.

IEEE Transactions on Medical Imaging, 37(12), p. 2642-2650

1558-254X

0278-0062

https://hdl.handle.net/1959.11/27931

Institute of Electrical and Electronics Engineers (IEEE)

High-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathology

Journal Article

Publication