Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/27931
Title: High-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathology
Contributor(s): Baran, Patrycja (author); Mayo, Sheridan (author); McCormack, Mikkaela (author); Pacile, Serena (author); Tromba, Giuliana (author); Dullin, Christian (author); Zanconati, Fabrizio (author); Arfelli, Fulvia (author); Dreossi, Diego (author); Fox, Jane (author); Prodanovic, Zdenka (author); Cholewa, Marian (author); Quiney, Harry (author); Dimmock, Matthew (author); Nesterets, Yakov  (author); Thompson, Darren (author); Brennan, Patrick (author); Gureyev, Timur  (author)orcid 
Publication Date: 2018-12
Early Online Version: 2018-06-11
DOI: 10.1109/TMI.2018.2845905
Handle Link: https://hdl.handle.net/1959.11/27931
Abstract: Histopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained 1.2 μm pixel size images, which were analyzed and compared with corresponding histological sections examined under light microscopy. To evaluate the effect of spatial resolution on breast cancer diagnosis, scans with four different pixel sizes were also performed. Our comparative analysis revealed that high-resolution images can enable, at a near-histological level, detailed architectural assessment of tissue that may permit increased breast cancer diagnostic sensitivity and specificity when compared with current imaging practices. The potential clinical applications of this method are also discussed.
Publication Type: Journal Article
Source of Publication: IEEE Transactions on Medical Imaging, 37(12), p. 2642-2650
Publisher: Institute of Electrical and Electronics Engineers
Place of Publication: United States of America
ISSN: 1558-254X
0278-0062
Field of Research (FOR): 111202 Cancer Diagnosis
Socio-Economic Outcome Codes: 970111 Expanding Knowledge in the Medical and Health Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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