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|Title:||High-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathology||Contributor(s):||Baran, Patrycja (author); Mayo, Sheridan (author); McCormack, Mikkaela (author); Pacile, Serena (author); Tromba, Giuliana (author); Dullin, Christian (author); Zanconati, Fabrizio (author); Arfelli, Fulvia (author); Dreossi, Diego (author); Fox, Jane (author); Prodanovic, Zdenka (author); Cholewa, Marian (author); Quiney, Harry (author); Dimmock, Matthew (author); Nesterets, Yakov (author); Thompson, Darren (author); Brennan, Patrick (author); Gureyev, Timur (author)||Publication Date:||2018-12||Early Online Version:||2018-06-11||DOI:||10.1109/TMI.2018.2845905||Handle Link:||https://hdl.handle.net/1959.11/27931||Abstract:||Histopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained 1.2 μm pixel size images, which were analyzed and compared with corresponding histological sections examined under light microscopy. To evaluate the effect of spatial resolution on breast cancer diagnosis, scans with four different pixel sizes were also performed. Our comparative analysis revealed that high-resolution images can enable, at a near-histological level, detailed architectural assessment of tissue that may permit increased breast cancer diagnostic sensitivity and specificity when compared with current imaging practices. The potential clinical applications of this method are also discussed.||Publication Type:||Journal Article||Source of Publication:||IEEE Transactions on Medical Imaging, 37(12), p. 2642-2650||Publisher:||Institute of Electrical and Electronics Engineers||Place of Publication:||United States of America||ISSN:||1558-254X
|Field of Research (FOR):||111202 Cancer Diagnosis||Socio-Economic Outcome Codes:||970111 Expanding Knowledge in the Medical and Health Sciences||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal|
|Appears in Collections:||Journal Article|
School of Science and Technology
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