Pincombe, Nick L; Pearson, Melissa J; Smart, Neil A; King, Nicola; Dieberg, Gudrun

Author(s)

Pincombe, Nick L

Pearson, Melissa J

Smart, Neil A

King, Nicola

Dieberg, Gudrun

Publication Date

2019-12

Abstract

Background and aims: Atherogenesis and endothelial dysfunction contribute to cardiovascular risk and vitamin D has been implemented in endothelial repair. This systematic review, meta-analysis and meta-regression aims to establish the effect of vitamin D supplementation on endothelial function. Methods and Results: To conduct the systematic review we searched the Cochrane Library of Controlled Trials, PubMed, ProQuest and EMBASE for randomized controlled trials that investigated the effects of vitamin D supplementation on flow-mediated dilation (FMD%), pulse wave velocity (PWV), and central augmentation index (AIx). Meta-analysis was based on a random effects model and inverse-variance methods to calculate either mean difference (MD) or standardized mean difference (SMD) as effects sizes. This was followed by meta-regression investigating the effect of baseline vitamin D concentrations, vitamin D dosing and study duration. Risk of bias was assessed using the JADAD scale and funnel plots. We identified 1056 studies of which 26 studies met inclusion criteria for quantitative analysis. Forty-two percent of the 2808 participants had either deficient or insufficient levels of vitamin D. FMD% (MD 1.17% (95% CI −0.20, 2.54), p = 0.095), PWV (SMD −0.09 m/s (95% CI −0.24, 0.07), p = 0.275) and AIx (SMD 0.05% (95% CI −0.1, 0.19), p = 0.52) showed no improvement with vitamin D supplementation. Sub-analysis and meta-regression revealed a tendency for AIx and FMD% to increase as weekly vitamin doses increased; no other significant relationships were identified. Conclusions: Vitamin D supplementation showed no improvement in endothelial function. More evidence is required before recommendations for management of endothelial dysfunction can be made.

Citation

Nutrition, Metabolism and Cardiovascular Diseases, 29(12), p. 1261-1272

ISSN

1590-3729

0939-4753

Pubmed ID

31653512

Link

https://hdl.handle.net/1959.11/27794

Publisher

Elsevier Ltd

Title

Effect of vitamin D supplementation on endothelial function - An updated systematic review with meta-analysis and meta-regression

Type of document

Journal Article

Entity Type

Publication

Author(s)	Pincombe, Nick L Pearson, Melissa J Smart, Neil A King, Nicola Dieberg, Gudrun
Publication Date	2019-12
Abstract	Background and aims: Atherogenesis and endothelial dysfunction contribute to cardiovascular risk and vitamin D has been implemented in endothelial repair. This systematic review, meta-analysis and meta-regression aims to establish the effect of vitamin D supplementation on endothelial function. Methods and Results: To conduct the systematic review we searched the Cochrane Library of Controlled Trials, PubMed, ProQuest and EMBASE for randomized controlled trials that investigated the effects of vitamin D supplementation on flow-mediated dilation (FMD%), pulse wave velocity (PWV), and central augmentation index (AIx). Meta-analysis was based on a random effects model and inverse-variance methods to calculate either mean difference (MD) or standardized mean difference (SMD) as effects sizes. This was followed by meta-regression investigating the effect of baseline vitamin D concentrations, vitamin D dosing and study duration. Risk of bias was assessed using the JADAD scale and funnel plots. We identified 1056 studies of which 26 studies met inclusion criteria for quantitative analysis. Forty-two percent of the 2808 participants had either deficient or insufficient levels of vitamin D. FMD% (MD 1.17% (95% CI −0.20, 2.54), p = 0.095), PWV (SMD −0.09 m/s (95% CI −0.24, 0.07), p = 0.275) and AIx (SMD 0.05% (95% CI −0.1, 0.19), p = 0.52) showed no improvement with vitamin D supplementation. Sub-analysis and meta-regression revealed a tendency for AIx and FMD% to increase as weekly vitamin doses increased; no other significant relationships were identified. Conclusions: Vitamin D supplementation showed no improvement in endothelial function. More evidence is required before recommendations for management of endothelial dysfunction can be made.
Citation	Nutrition, Metabolism and Cardiovascular Diseases, 29(12), p. 1261-1272
ISSN	1590-3729 0939-4753
Pubmed ID	31653512
Link	https://hdl.handle.net/1959.11/27794
Publisher	Elsevier Ltd
Title	Effect of vitamin D supplementation on endothelial function - An updated systematic review with meta-analysis and meta-regression
Type of document	Journal Article
Entity Type	Publication

Effect of vitamin D supplementation on endothelial function - An updated systematic review with meta-analysis and meta-regression

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