Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/27302
Title: Genetic architecture of resistance to virulent ovine-footrot in a case-control study of New Zealand Merino sheep
Contributor(s): Raadsma, H W (author); Walkom, S F  (author)orcid ; Sharland, B (author); Esquivelzeta-Rabell, C  (author); Brown, D J  (author)orcid ; Bunter, K L  (author)orcid ; Ferguson, M (author)
Publication Date: 2018
Open Access: Yes
Handle Link: https://hdl.handle.net/1959.11/27302
Open Access Link: http://www.wcgalp.org/proceedings/2018/genetic-architecture-resistance-virulent-ovine-footrot-case-control-study-newOpen Access Link
Abstract: The genetic architecture of resistance and susceptibility to virulent ovine footrot was studied in a cohort of 3,208 animals from 37 informative flocks of predominant Merino (93%), and Merino Types (Poll Merino, Dohne and South African Meat Merino). Footrot was scored as a binary trait where an animal was scored as affected (1) or unaffected (0, free from footrot), after 2 known challenges. For final analysis, animals from flocks with a prevalence in the range of 30-70% were selected. Animals were genotyped with either a 50K or 15K SNP panel on the Illumina Ovine bead array resulting in combined imputed SNP genotype for 51,713 markers for all animals. The animals were of mixed ages (lambs, yearlings, hoggets and adults), sexes, and breeds. Heritability of footrot was 0.39 ± 0.04 based on a genomic relationship matrix on the underlying scale. Corresponding proportional chromosome heritabilities were in the range of 0.00 ± 0.01 (OAR12) to 0.14 ± 0.04 (OAR23) and compared against expected based on chromosome length. Two markers on OAR23 accounted for a significant component of the additive genetic variance, whilst all residual SNP markers failed to reach statistical significance, despite being located on chromosomes with disproportionate effect on the genetic variance. The polygenic nature of genetic variation in resistance to footrot is discussed.
Publication Type: Conference Publication
Conference Details: WCGALP 2018: 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11th - 16th February, 2018
Source of Publication: Proceedings of the World Congress on Genetics Applied to Livestock Production, v.11, p. 1-6
Publisher: Massey University
Place of Publication: Palmerston North, New Zealand
Fields of Research (FoR) 2008: 070201 Animal Breeding
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
Socio-Economic Objective (SEO) 2008: 830311 Sheep - Wool
Socio-Economic Objective (SEO) 2020: 100413 Sheep for wool
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Publisher/associated links: http://www.wcgalp.org/proceedings/2018
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Conference Publication

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