Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/27079
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tully, P | en |
dc.contributor.author | Hanon, O | en |
dc.contributor.author | Cosh, S | en |
dc.contributor.author | Tzourio, C | en |
dc.date.accessioned | 2019-06-03T06:07:40Z | - |
dc.date.available | 2019-06-03T06:07:40Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | v.33, p. S87 | en |
dc.identifier.issn | 1778-3585 | en |
dc.identifier.issn | 0924-9338 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/27079 | - |
dc.description.abstract | Introduction: Numerous observational studies suggest that blood pressure management with antihypertensive drugs may be effective in reducing dementia risk. Objective: To quantify dementia risk in relation to diuretic medication use. Methods: Electronic databases were searched until June 2015. Eligibility criteria: population, adults without dementia at baseline from primary care, community cohort, residential/institutionalized or randomized controlled trial (RCT); exposure, diuretic medication; comparison, no diuretic medication, other or no antihypertensive medication, placebo-control; outcome, incident dementia in accordance with standardized criteria. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) were pooled in fixed-effects models with RevMan 5.3. The overall quality and strength of evidence was rated with GRADE criteria. Results: Fifteen articles were eligible comprising a pooled sample of 52,599 persons and 3444 incident dementia cases (median age 76.1 years, 40% male) with a median follow-up of 6.1 years. Diuretic use was associated with 17% reduction in dementia risk (HR 0.83; 95% CI 0.75 to 0.90) and a 21% reduction in Alzheimer's disease risk (HR 0.79; 95% CI 0.68 to 0.93). GRADE was rated as moderate. Risk estimates were consistent comparing monotherapy versus combination therapy, study design and follow-up. Meta-regression did not suggest that age, gender, systolic blood pressure, attrition, mortality rate, education, cognitive function, stroke, Apolipoprotein E allele, heart failure or diabetes altered the primary results. Conclusions: Diuretic medication was associated with a consistent reduction in dementia and Alzheimer's disease risk and the absence of heterogeneity points to the generalizability of these findings. | en |
dc.language | en | en |
dc.publisher | Elsevier Masson | en |
dc.title | Diuretic medication use reduces incident dementia risk: A meta-analysis of prospective studies | en |
dc.type | Conference Publication | en |
dc.relation.conference | EPA 2016: 24th European Congress of Psychiatry | en |
dc.identifier.doi | 10.1016/j.eurpsy.2016.01.044 | en |
local.contributor.firstname | P | en |
local.contributor.firstname | O | en |
local.contributor.firstname | S | en |
local.contributor.firstname | C | en |
local.subject.for2008 | 110319 Psychiatry (incl. Psychotherapy) | en |
local.subject.for2008 | 170102 Developmental Psychology and Ageing | en |
local.subject.seo2008 | 920410 Mental Health | en |
local.subject.seo2008 | 920502 Health Related to Ageing | en |
local.profile.school | School of Psychology | en |
local.profile.school | School of Psychology | en |
local.profile.email | ptully2@une.edu.au | en |
local.profile.email | scosh@une.edu.au | en |
local.output.category | E3 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.date.conference | 12th - 15th March, 2016 | en |
local.conference.place | Madrid, Spain | en |
local.publisher.place | France | en |
local.identifier.runningnumber | FC40 | en |
local.format.startpage | S87 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 33 | en |
local.title.subtitle | A meta-analysis of prospective studies | en |
local.contributor.lastname | Tully | en |
local.contributor.lastname | Hanon | en |
local.contributor.lastname | Cosh | en |
local.contributor.lastname | Tzourio | en |
dc.identifier.staff | une-id:ptully2 | en |
dc.identifier.staff | une-id:scosh | en |
local.profile.orcid | 0000-0003-2807-1313 | en |
local.profile.orcid | 0000-0002-8003-3704 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/27079 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Diuretic medication use reduces incident dementia risk | en |
local.output.categorydescription | E3 Extract of Scholarly Conference Publication | en |
local.relation.url | http://2016.epa-congress.org/ | en |
local.conference.details | EPA 2016: 24th European Congress of Psychiatry, Madrid, Spain, 12th - 15th March, 2016 | en |
local.search.author | Tully, P | en |
local.search.author | Hanon, O | en |
local.search.author | Cosh, S | en |
local.search.author | Tzourio, C | en |
local.uneassociation | Unknown | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/60713cfe-af26-424d-ae68-405b96e22f74 | en |
local.subject.for2020 | 320221 Psychiatry (incl. psychotherapy) | en |
local.subject.for2020 | 520101 Child and adolescent development | en |
local.subject.for2020 | 520106 Psychology of ageing | en |
local.subject.seo2020 | 200409 Mental health | en |
local.subject.seo2020 | 200502 Health related to ageing | en |
dc.notification.token | cffdfc50-9345-4bb1-8d0a-96c5f5ab7875 | en |
local.date.start | 2016-03-12 | - |
local.date.end | 2016-03-15 | - |
Appears in Collections: | Conference Publication School of Psychology |
Files in This Item:
File | Size | Format |
---|
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.