Please use this identifier to cite or link to this item:
Title: The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol
Contributor(s): Tully, Phillip J  (author)orcid ; Turnbull, Deborah A (author); Anstey, Kaarin J (author); Beckett, Nigel (author); Beiser, Alexa S (author); Birns, Jonathan (author); Brickman, Adam M (author); Burns, Nicholas R (author); Cosh, Suzanne  (author)orcid ; de Leeuw, Peter W (author); Dorstyn, Diana (author); Elias, Merril F (author); Jukema, J Wouter (author); Kario, Kazuomi (author); Kikuya, Masahiro (author); Kroon, Abraham A (author); Launer, Lenore J (author); Mahajan, Rajiv (author); McGrath, Emer R (author); Mooijaart, Simon P (author); Moll van Charante, Eric P (author); Nagai, Michiaki (author); Ninomiya, Toshiharu (author); Ohara, Tomoyuki (author); Ohkubo, Takayoshi (author); Oishi, Emi (author); Peters, Ruth (author); Richard, Edo (author); Satoh, Michihiro (author); Seshadri, Sudha (author); Stott, David J (author); van Gool, Willem A (author); van Middelaar, Tessa (author); Trompet, Stella (author); Giles, Kristy (author); Drioli-Phillips, Phoebe (author); Aaimir, Umama (author); Connolly, Frank (author); Tzourio, Christophe (author)
Corporate Author: Variable Brain Consortium
Publication Date: 2018-10-15
Open Access: Yes
DOI: 10.1186/s13643-018-0811-9
Handle Link:
Abstract: Background: A body of empirical work demonstrates that wide fluctuations in a person's blood pressure across consecutive measures, known as blood pressure variability (BPV), hold prognostic value to predict stroke and transient ischemic attack. However, the magnitude of association between BPV and other neurological outcomes remains less clear. This systematic review aims to pool together data regarding BPV with respect to incident dementia, cognitive impairment, and cognitive function. Methods: Electronic databases (MEDLINE, EMBASE, and SCOPUS) will be searched for the key words blood pressure variability and outcomes of dementia, cognitive impairment, and cognitive function. Authors and reference lists of included studies will also be contacted to identify additional published and unpublished studies. Eligibility criteria are as follows: population-adult humans (over 18 years but with no upper age limit) without dementia at baseline, with or without elevated blood pressure, or from hypertensive populations (systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg or use of antihypertensive drug for hypertension) and from primary care, community cohort, electronic database registry, or randomized controlled trial (RCT); exposure-any metric of BPV (systolic, diastolic or both) over any duration; comparison-persons without dementia who do not have elevated BPV; and outcome-dementia, cognitive impairment, cognitive function at follow-up from standardized neurological assessment, or cognitive testing. Article screening will be undertaken by two independent reviewers with disagreements resolved through discussion. Data extraction will include original data specified as hazard ratios, odds ratios, correlations, regression coefficients, and original cell data if available. Risk of bias assessment will be undertaken by two independent reviewers. Meta-analytic methods will be used to synthesize the data collected relating to the neurological outcomes with Comprehensive Meta-Analysis Version 2.0 (Biostat Inc., Engelwood, NJ). Discussion: This systematic review aims to clarify whether BPV is associated with elevated risk for dementia, cognitive impairment, and cognitive function. An evaluation of the etiological links between BPV with incident dementia might inform evidence-based clinical practice and policy concerning blood pressure measurement and hypertension management. The review will identify sources of heterogeneity and may inform decisions on whether it is feasible and desirable to proceed with an individual participant data meta-analysis.
Publication Type: Journal Article
Source of Publication: Systematic Reviews, v.7, p. 1-8
Publisher: BioMed Central Ltd
Place of Publication: United Kingdom
ISSN: 2046-4053
Fields of Research (FoR) 2008: 170102 Developmental Psychology and Ageing
110319 Psychiatry (incl. Psychotherapy)
Fields of Research (FoR) 2020: 520106 Psychology of ageing
520101 Child and adolescent development
320221 Psychiatry (incl. psychotherapy)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
920502 Health Related to Ageing
970111 Expanding Knowledge in the Medical and Health Sciences
Socio-Economic Objective (SEO) 2020: 200502 Health related to ageing
280114 Expanding knowledge in Indigenous studies
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Psychology

Files in This Item:
2 files
File Description SizeFormat 
openpublished/TheAssociationBetweenCosh2018JournalArticle.pdfPublished version369.64 kBAdobe PDF
Download Adobe
Show full item record
Google Media

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons