Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26841
Title: Significance of Anti-Myosin Antibody Formation in Patients With Myocardial Infarction: A Prospective Observational Study
Contributor(s): O'Donohoe, Tom J (author); Schrale, Ryan G (author); Sikder, Suchandan  (author); Surve, Nuzhat (author); Rudd, Donna (author); Ketheesan, Natkunam  (author)orcid 
Publication Date: 2019-04
DOI: 10.1016/j.hlc.2018.03.008
Handle Link: https://hdl.handle.net/1959.11/26841
Abstract: 

Background
Anti-myosin antibodies (AMAs) are often formed in response to myocardial infarction (MI) and have been implicated in maladaptive cardiac remodelling. We aimed to: (1) compare AMA formation in patients with Non-ST-Elevation MI (NSTEMI) and ST-Elevation MI (STEMI); (2) evaluate factors predicting autoantibody formation; and, (3) explore their functional significance.

Methods
Immunoglobulin M (IgM) and Immunoglobulin G (IgG) AMA titres were determined in serum samples collected at admission, 3 and 6 months post MI. The relationship between demographic and clinical data, and antibody formation, was investigated to determine factors predicting antibody formation and functional significance.

Results
Forty-three (43) patients were consecutively recruited; 74.4% were positive for IgM at admission, compared with 23.3% for IgG. Mean IgG levels increased by 1.24% (±0.28) at 3 months, and 13.55% (±0.13) at 6 months post MI. Mean antibody levels were significantly higher in the NSTEMI cohort at both follow-up time points for IgG (p < 0.001, p < 0.0001), but not IgM (p = 0.910, p = 0.066). A moderately positive correlation between infarct size and increase in mean IgM concentration was observed at 3 months (r(98) = 0.455; p = 0.015). Anti-myosin antibody formation was not associated with an unfavourable outcome at follow-up.

Conclusions
Anti-myosin antibodies are formed in a significant proportion of patients following MI, particularly among those with NSTEMI. While IgM levels fall after infarction, IgG levels increase and persist beyond 6 months of follow-up. This raises the possibility that they may contribute to long-term myocardial damage and dysfunction. Future research should focus on the specific epitopes that are targeted by these antibodies, and their functional significance. This may result in the emergence of novel therapies to attenuate cardiac dysfunction in MI patients.

Publication Type: Journal Article
Source of Publication: Heart, Lung and Circulation, 28(4), p. 583-590
Publisher: Elsevier Australia
Place of Publication: Australia
ISSN: 1444-2892
1443-9506
Fields of Research (FoR) 2008: 119999 Medical and Health Sciences not elsewhere classified
Fields of Research (FoR) 2020: 320803 Systems physiology
Socio-Economic Objective (SEO) 2008: 920109 Infectious Diseases
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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