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|Title:||Dietary L-glutamine supplementation improves growth performance, gut morphology, and serum biochemical indices of broiler chickens during necrotic enteritis challenge||Contributor(s):||Xue, G D (author); Barekatain, R (author); Wu, S B (author) ; Choct, M (author) ; Swick, R A (author)||Publication Date:||2018-04||Early Online Version:||2018-03-15||Open Access:||Yes||DOI:||10.3382/ps/pex444||Handle Link:||https://hdl.handle.net/1959.11/26761||Abstract:||Necrotic enteritis (NE) causes significant economic losses in the broiler chicken industry, especially in birds raised without in-feed antibiotics. L–glutamine (Gln) is an amino acid that may compensate for metabolic losses from infection and improve the intestinal development. This study investigated the effects of dietary Gln (10 g/kg) supplementation on growth performance, intestinal lesions, jejunum morphology, and serum biochemical indices of broiler chickens during NE challenge. The study employed a factorial arrangement of treatments with factors: NE challenge, no or yes; dietary Gln inclusion, 0 g/kg in starter (S), d 0 to 10, grower (G) d 10 to 24, and finisher (F) d 24 to 35; 10 g/kg in S, G, F, or 10 g/kg in S, G only. Each treatment was replicated in 6 floor pens with 17 birds per pen as the experimental unit for performance and 2 birds for other measurements. Challenge significantly reduced bird performance, increased incidence of intestinal lesions, and affected intestinal development and serum biochemical indices. Regardless of challenge, Gln supplementation increased gain (𝑃 < 0.05), feed intake (𝑃 < 0.05), and decreased FCR (𝑃 < 0.05) on d 24. On d 35, Gln improved gain (𝑃 < 0.05) and FCR (𝑃 < 0.001) whereas withdrawing Gln from finisher tended to diminish the beneficial effect on weight gain but not FCR. Dietary Gln reduced lesion scores in the jejunum (𝑃 < 0.01) and ileum (𝑃 < 0.01) in challenged birds. On d 16, Gln increased villus height to crypt depth ratio in unchallenged birds (𝑃 < 0.05) and reduced crypt depth of challenged birds on d 24 (𝑃 < 0.05). Regardless of challenge, supplementation with Gln reduced crypt depth on d 16 (𝑃 < 0.05), and increased villus height (𝑃 < 0.01) and the villus height to crypt depth ratio (𝑃 < 0.001) on d 24. Dietary Gln lowered serum uric acid level regardless of challenge (𝑃 < 0.05). The current study indicates that dietary Gln alleviates adverse effects of NE and may be useful in antibiotic-free diets.||Publication Type:||Journal Article||Source of Publication:||Poultry science, 97(4), p. 1334-1341||Publisher:||Oxford University Press||Place of Publication:||United States of America||ISSN:||0032-5791
|Field of Research (FOR):||070204 Animal Nutrition||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal|
|Appears in Collections:||Journal Article|
School of Environmental and Rural Science
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