Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26677
Title: Exercise-based cardiac rehabilitation improves exercise capacity and health-related quality of life in people with atrial fibrillation: a systematic review and meta-analysis of randomised and non-randomised trials
Contributor(s): Smart, Neil A  (author)orcid ; King, Nicola (author); Lambert, Jeffrey D (author); Pearson, Melissa J  (author); Campbell, John L (author); Risom, Signe S (author); Taylor, Rod S (author)
Publication Date: 2018
Early Online Version: 2018-12-20
Open Access: Yes
DOI: 10.1136/openhrt-2018-000880Open Access Link
Handle Link: https://hdl.handle.net/1959.11/26677
Abstract: Objective: The aim of this study was to undertake a contemporary review of the impact of exercise-based cardiac rehabilitation (CR) targeted at patients with atrial fibrillation (AF). Methods: We conducted searches of PubMED, EMBASE and the Cochrane Library of Controlled Trials (up until 30 November 2017) using key terms related to exercise-based CR and AF. Randomised and non-randomised controlled trials were included if they compared the effects of an exercise-based CR intervention to a no exercise or usual care control group. Meta-analyses of outcomes were conducted where appropriate. Results: The nine randomised trials included 959 (483 exercise-based CR vs 476 controls) patients with various types of AF. Compared with control, pooled analysis showed no difference in all-cause mortality (risk ratio (RR) 1.08, 95% CI 0.77 to 1.53, p=0.64) following exercise-based CR. However, there were improvements in health-related quality of life (mean SF-36 mental component score (MCS): 4.00, 95% CI 0.26 to 7.74; p=0.04 and mean SF-36 physical component score: 1.82, 95% CI 0.06 to 3.59; p=0.04) and exercise capacity (mean peak VO₂: 1.59ml/kg/min, 95% CI 0.11 to 3.08; p=0.04; mean 6 min walk test: 46.9 m, 95% CI 26.4 to 67.4; p<0.001) with exercise-based CR. Improvements were also seen in AF symptom burden and markers of cardiac function. Conclusions: Exercise capacity, cardiac function, symptom burden and health-related quality of life were improved with exercise-based CR in the short term (up to 6 months) targeted at patients with AF. However, high-quality multi-centre randomised trials are needed to clarify the impact of exercise-based CR on key patient and health system outcomes (including health-related quality of life, mortality, hospitalisation and costs) and how these effects may vary across AF subtypes.
Publication Type: Journal Article
Source of Publication: Open Heart, 5(2), p. 1-11
Publisher: BMJ Group
Place of Publication: United Kingdom
ISSN: 2053-3624
Fields of Research (FoR) 2008: 110602 Exercise Physiology
110201 Cardiology (incl. Cardiovascular Diseases)
Fields of Research (FoR) 2020: 420702 Exercise physiology
320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

36
checked on Mar 16, 2024

Page view(s)

1,484
checked on May 7, 2023
Google Media

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons