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Title: Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
Contributor(s): Sharpley, Christopher F  (author)orcid ; Bitsika, Vicki  (author)orcid ; McMillan, Mary E  (author)orcid ; Jesulola, Emmanuel (author); Agnew, Linda L  (author)orcid 
Publication Date: 2018-08-10
Open Access: Yes
DOI: 10.2147/NDT.S168291Open Access Link
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Abstract: Purpose: Depression remains difficult to treat in all cases, and further investigation of the role of genetic and environmental factors may be valuable. This study was designed to investigate the association between the short (s) versus non-short (non-s) 5HTTLPR variants, presence of childhood stressors and recent life stressors, and depression, and to do so at two levels that would expose the associations between total depression scores and also individual depression items. Materials and methods: Two hundred and forty-nine volunteers from one of the Australian Electoral Office electorates covering a large rural land area completed a series of questionnaires about childhood and recent life stress and depression, and provided a buccal cell sample for genotyping the 5-HTTLPR polymorphism into s versus non-s carriers. Results: Although there were no significant differences in the depression scores of the s-carriers versus the non-s carriers, each subtype of the 5-HTTLPR polymorphism showed different patterns of association between childhood stress and depression symptoms, and between recent life stress and depression symptoms. Conclusion: Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology.
Publication Type: Journal Article
Source of Publication: Neuropsychiatric Disease and Treatment, v.14, p. 2007-2016
Publisher: Dove Medical Press Ltd
Place of Publication: United Kingdom
ISSN: 1178-2021
Field of Research (FOR): 110999 Neurosciences not elsewhere classified
Socio-Economic Outcome Codes: 920111 Nervous System and Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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