Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians

Title
Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
Publication Date
2018-08-10
Author(s)
Sharpley, Christopher F
( author )
OrcID: https://orcid.org/0000-0001-7922-4848
Email: csharpl3@une.edu.au
UNE Id une-id:csharpl3
Bitsika, Vicki
( author )
OrcID: https://orcid.org/0000-0003-2518-6684
Email: vbitsik2@une.edu.au
UNE Id une-id:vbitsik2
McMillan, Mary E
( author )
OrcID: https://orcid.org/0000-0002-2336-3985
Email: mrookle2@une.edu.au
UNE Id une-id:mrookle2
Jesulola, Emmanuel
Agnew, Linda L
( author )
OrcID: https://orcid.org/0000-0002-2803-0995
Email: lagnew2@une.edu.au
UNE Id une-id:lagnew2
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Dove Medical Press Ltd
Place of publication
United Kingdom
DOI
10.2147/NDT.S168291
UNE publication id
une:1959.11/26655
Abstract
Purpose: Depression remains difficult to treat in all cases, and further investigation of the role of genetic and environmental factors may be valuable. This study was designed to investigate the association between the short (s) versus non-short (non-s) 5HTTLPR variants, presence of childhood stressors and recent life stressors, and depression, and to do so at two levels that would expose the associations between total depression scores and also individual depression items. Materials and methods: Two hundred and forty-nine volunteers from one of the Australian Electoral Office electorates covering a large rural land area completed a series of questionnaires about childhood and recent life stress and depression, and provided a buccal cell sample for genotyping the 5-HTTLPR polymorphism into s versus non-s carriers. Results: Although there were no significant differences in the depression scores of the s-carriers versus the non-s carriers, each subtype of the 5-HTTLPR polymorphism showed different patterns of association between childhood stress and depression symptoms, and between recent life stress and depression symptoms. Conclusion: Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology.
Link
Citation
Neuropsychiatric Disease and Treatment, v.14, p. 2007-2016
ISSN
1178-2021
Pubmed ID
30127611
Start page
2007
End page
2016

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